EIF2C1

(redirected from argonaute1)

EIF2C1

A gene on chromosome 1p34.3 that encodes a protein required for RNA-mediated gene silencing, binding to short RNAs, such as microRNAs or short interfering RNAs, and repressing the translation of mRNAs complementary to them. EIF2C1 lacks endonuclease activity and does not appear to cleave target mRNAs. It is required for transcriptional gene silencing of promoter regions which are complementary to bound short anti-gene RNA.
References in periodicals archive ?
Aida et al., "The PINHEAD/ ZWILLE gene acts pleiotropically in Arabidopsis development and has overlapping functions with the ARGONAUTE1 gene," Development, vol.
Arabidopsis ARGONAUTE1 is an RNA slicer that selectively recruits microRNAs and short interfering RNAs.
Baulcombe, "Arabidopsis ARGONAUTE1 is an RNA Slicer that selectively recruits microRNAs and short interfering RNAs," Proceedings of the National Academy of Sciences of the United States of America, vol.
BARTEL (2004): <<The Action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development>>, Genes & Developement, vol.
Plant virus mediated induction of miR168 is associated with repression of ARGONAUTE1 accumulation.
Martienssen, "Spatially restricted microRNA directs leaf polarity through ARGONAUTE1," Nature, vol.
Argonaute1 and Argonaute10 are involved in shoot meristem, Argonaute4 is involved in RNA-directed DNA methylation and silencing of a small class of transposons, and Argonaute7 is involved in the juvenile-adult transition in vegetative development [13, 21].