Bacteriocins are in general cationic, amphipathic molecules as they contain an excess of lysyl and arginyl
The mechanism of L-canavanine cytotoxicity: Arginyl
tRNA synthetase as a novel target for anticancer drug discovery, j.
Nikolova first gave 40 men, aged 25 to 45, a dipeptide arginyl
aspartate solution called Sargenor three times per day (equivalent to 1.
The gut showed highest activities of alanyl aminopeptidase, dipeptidyl aminopeptidase (DAP) I, II and IV, and cathepsin B, L and H while head showed highest activities of arginyl, leucyl and tripeptidyl aminopeptidase.
DAP I by 429%, DAP II by 355% and DAP IV by 178%, followed by cathepsin L (246%), cathepsin D (123%), tripeptidyl aminopeptidase (109%), arginyl aminopeptidase (78%), alanyl aminopeptidase (72%), leucyl aminopeptidase (49%), cathepsin H (37%) and proline endopeptidase (19%).
After treatment with arginyl
aspartate (which provided the equivalent of 1.
The ND3/ND4 region begins in the glycyl tRNA gene and spans the NADH-dehydrogenase subunit-3, arginyl
tRNA, NADH-dehydrogenase subunit-4L, and NADH-dehydrogenase subunit-4 genes, ending in the histidyl tRNA gene.
sup] Once CRT translocates to the cytosol, it can be posttranslationally modified by arginyl
transferase, which attaches an arginine residue to the N-terminal aspartic acid residue of the protein and localizes CRT to cytoplasmic stress granules.
Thus alanyl aminopeptidase was increased by 53%, arginyl
aminopeptidase by 73%, leucyl aminopeptidase by 16%, dipeptidyl aminopeptidase IV by 17%, tripeptidyl aminopeptidase by 148% and proline endopeptidase by 111%.
Furthermore, we found that trypsin treatment of plasma efficiently cleaves the endogenous N-terminal proBNP forms after the arginyl
residue in position 21 (Fig.
Purification and characterization of two soluble Cl-activated arginyl
aminopeptidases from human brain and their endopeptidase action on neuropeptides.
Evidence indicates that the arginyl
residue at the carboxyl terminus is also removed.