Eryminase, a product candidate being developed by Erytech, consists of an arginine deiminase
enzyme encapsulated in red blood cells using Erytech's proprietary ERYCAPS platform technology.
Mowen, "ATP induces protein arginine deiminase
2-dependent citrullination in mast cells through the P2X7 purinergic receptor," The Journal of Immunology, vol.
BMS gains full rights to Padlock's Protein/Peptidyl Arginine Deiminase
(PAD) inhibitor discovery program focused on transformational treatment approaches for rheumatoid arthritis (RA), as well as systemic lupus erythematosus (SLE) and other autoimmune diseases.
Bristol-Myers Squibb said the deal will give it full rights to Padlock's Protein/Peptidyl Arginine Deiminase
inhibitor discovery program focused on the development of potentially transformational treatment approaches for patients with rheumatoid arthritis.
Pegylated arginine deiminase
(ADI-SS [PEG.sub.20.000 mw]) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo.
Porphyromonas gingivalis (Pg) is a significant periodontal pathogen; it is the only bacterium known to possess a peptidyl arginine deiminase
(PAD) which generates a citrullinated peptide by posttranslational modification (citrullination) of protein bound arginine; the citrullinated peptide and anticyclic citrullinated peptide (anti-CCP) autoantibody are capable of breaking down self tolerance and lead to the development of autoimmune RA.
(7) Genomewide association studies have identified variants in potentially pathogenic genes in non-HLA regions, including PTPN22 (8) [protein tyrosine phosphatase, non-receptor type 22 (lymphoid)], the TRAF1-C5 locus [TRAF1 (TNF receptor-associated factor 1) to C5 (complement component 5)], PADI4 (peptidyl arginine deiminase
, type IV), and STAT4 (signal transducer and activator of transcription 4).
This hypothesis is supported by expression of arcA, arcB, arcC, and arcD, genes predicted to encode an arginine deiminase
, an ornithine carbamoyltransferase, a carbamate kinase, and an arginine/ornithine antiporter, respectively (Table 3).
In vitro studies with recombinant arginine deiminase
showed that the secreted Giardia proteins could disable host innate immune factors such as nitric oxide production.
Genome sequence data from multidrug-resistant USA300 strain FPR3757 showed that it has a novel mobile genetic element that contains genes for enzymes of the arginine deiminase
pathway and an oligopeptide permease system (16).