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However arginine has many physiological roles in the body and as it uses the same intracellular transport routes as lysine there is the potential for adverse effects due to a relative arginine deficiency.
8) Arginine deficiency is also a feature of sickle cell disease.
7) In one patient with small intestine and kidney damage an arginine deficiency led to hyperammonemia and resultant disturbed consciousness, which were corrected with supplemental arginine.
There is however, the potential for lysine to be counterproductive long term due to competition with arginine for shared transport and a proposed relative arginine deficiency.
An inhibition of OAT will lead to decreased synthesis of citrulline and arginine from both glutamine and proline in enterocytes, thereby resulting in arginine deficiency, as in OAT-gene knockout mice (Wang et al.
They wrote: "One unusual finding comes from the laboratories of Eli Lilly and Company, Indianapolis, where in vitro data indicate that an arginine deficiency suppresses HSV-1 (herpes virus) replication.
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