argentaffin reaction

argentaffin reaction

A histologic reaction of waning popularity based on the reduction of ammonical silver to metallic silver, which was used to identify APUD (now known as neuroendocrine) cells.
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The Masson-Fontana silver method for melanin resulted positive and the pigments manifested a strong argentaffin reaction. In the extracellular space, pigment granules were abundant and dispersed throughout the parenchyma (Figure 2).
A strong argentaffin reaction is exhibited in pigmented cells (arrowheads) and in extracellular space.