area under the curve

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 [a´re-ah] (pl. a´reae, areas) (L.)
a limited space or plane surface.
acoustic a's auditory areas.
association a's areas of the cerebral cortex (excluding primary areas) connected with each other and with the neothalamus; they are responsible for higher mental and emotional processes, including memory, learning, speech, and the interpretation of sensations.
Area. Functional areas and lobes of the cerebrum.
auditory a's two contiguous areas of the temporal lobe in the region of the anterior transverse temporal gyrus, known as the primary and secondary auditory areas. Called also acoustic areas.
Broca's motor speech area an area comprising parts of the opercular and triangular portions of the inferior frontal gyrus; injury to this area may result in motor aphasia.
Broca's parolfactory area a small area of cortex on the medial surface of each cerebral hemisphere, between the anterior and posterior parolfactory sulci. Called also area subcallosa.
Brodmann's a's specific occipital and preoccipital areas of the cerebral cortex, distinguished by differences in the arrangement of their six cellular layers, and identified by numbering each area. They are considered to be the seat of specific functions of the brain.
catchment area
1. the geographical region drained by one body of water.
2. the area whose residents are served by a specialized health care agency. Called also catchment.
contact area proximal surface.
embryonic area (germinal area) (area germinati´va) embryonic disk.
Kiesselbach's area an area on the anterior part of the nasal septum, richly supplied with capillaries, and a common site of epistaxis (nosebleed).
language area any nerve center of the cerebral cortex, usually in the dominant hemisphere, controlling the understanding or use of language.
motor area any area of the cerebral cortex primarily involved in stimulating muscle contractions; most are in the precentral gyri. See also premotor area, sensorimotor area, and Broca's motor speech area.
motor speech area see Broca's motor speech area and Wernicke's area.
occupational performance a's categories of activities that make up an individual's occupational performance; they include activities of daily living, work activities, and play or leisure activities. A delay in any of these areas may be addressed by occupational therapy intervention.
olfactory area
1. a general area of the brain, including the olfactory bulb, tract, and trigone, the anterior portion of the gyrus cinguli, and the uncus.
postcentral area (postrolandic area) an area just posterior to the central sulcus of the cerebral hemisphere that is the primary receiving area for general sensations.
precentral area primary somatomotor area.
premotor area an area of the motor cortex of the frontal lobe immediately in front of the precentral gyrus.
primary area areas of the cerebral cortex comprising the motor and sensory regions.
primary receiving a's the areas of the cerebral cortex that receive the thalamic projections of the primary sensory modalities such as vision, hearing, and smell. Called also sensory areas.
primary somatomotor area an area in the posterior part of the frontal lobe just anterior to the central sulcus; different regions control motor activity of specific parts of the body. Called also precentral area and rolandic area.
projection a's those areas of the cerebral cortex that receive the most direct projection of the sensory systems of the body.
sensorimotor area the cortex of the precentral and postcentral gyri, which are the motor area and the primary receiving area for general sensations, respectively.
sensory a's primary receiving areas.
sensory association area an association area around the borders of a primary receiving area, where sensory stimuli are interpreted.
silent area an area of the brain in which pathologic conditions may occur without producing symptoms.
somatic sensory area (somatosensory area) either of two cortical projection areas in or near the postcentral gyrus where conscious perception of somatic sensations occurs, known as the first or primary somatosensory area and the second or secondary somatosensory area.
area subcallo´sa (subcallosal area) Broca's parolfactory area.
area under the curve (AUC) the area enclosed between the curve of a probability with nonnegative values and the axis of the quality being measured; of the total area under a curve, the proportion that falls between two given points on the curve defines a probability density function.
visual a's three areas (first, second, and third visual areas) of the visual cortex. The first visual area is better known as the striate cortex.
vocal area rima glottidis.
Wernicke's area originally a name for a speech center thought to be confined to the posterior part of the superior temporal gyrus next to the transverse temporal gyri; the term now refers to a wider zone that also includes the supramarginal and angular gyri.

area under the curve

Clinical pharmacology The amount of a therapeutic agent that is present in the circulation in a determined time period, often 24 hrs. See Therapeutic drug monitoring.

area under the curve



The integrated quantity of drug (the serum drug concentration with respect to time after taking a single dose).


a line that is not straight; the line representing varying values in a graph.

area under moment curve
plasma drug concentration × time after dosing versus time after drug administration.
area under the curve
the area under a plasma concentration versus time curve. A measure of drug absorption.
epidemic curve
a graphical representation showing the number of new cases of the disease plotted against time. A decision on when the new infection rate creates an epidemic varies with the disease and the circumstances. The rate would need to be clearly in excess of its expected frequency.
fitted curve
the theoretical frequency distribution whose closeness of fit to the subject data is under test.
freehand curve
a line drawn in by hand on a scattergram to establish the relationship between two variables.
frequency curve
a curve representing graphically the probabilities of different numbers of occurrences of an event.
logarithmic curve
the curve which demonstrates the straightline relationship between two variables when both of them are scaled as logarithms.
log dose-response curve
the standard way of presenting pharmacological data about a drug. The response is plotted against dose on a semilogarithmic graph. It has the advantage that a wide range of dose rates can be entered on the one graph.
plasma concentration-time curve
the plasma concentration of a drug plotted against time.
semilogarithmic curve
as for logarithmic curve except that only one of the variables is scaled as a logarithm. See also logarithmic relationship.
sigmoid curve
an S-shaped curve. A common curve in biological distributions.
survivorship curve
a graphic presentation of a life table. Obviously the proportion of survivors decreases with advancing age of the group.
vertebral curve
the downward curve of the thoracolumbar region and that of the cervical region in some animals.
References in periodicals archive ?
The z-score table indicates that this would contain 48% on each side or 96% of total area under the curve.
n] (where n is a natural number) the value for a which yields an area under the curve of measure 1 from x = 1 to x = a is given by
Major Finding: The area under the curve for postoperative pain scores while sitting was approximately 30% lower with subcutaneous bupivacaine plus ketorolac than with subcutaneous bupivacaine alone.
For the first 41 participants with full results available, caffeine increased the 3-hour area under the curve (AUC) for plasma glucose by 15% more than placebo, though the result was not statistically significant.
The investigators calculated insulin sensitivity and area under the curve (AUC) for glucose and insulin.
Primarily, everything about the process is represented by one number, which is the area under the curve," explains Watkins.
Further analysis found that Lp-PLA2 moves the area under the curve (AUC), demonstrating an improvement in predictive accuracy, even after addition of traditional risk factors and the novel biomarkers cystatin C and NT-proBNP.
The trial was a randomised, two-period, two-way crossover study in healthy male and female subjects which was designed to determine whether the product is safe and bioequivalent to a leading anti-migraine product as measured by industry standard pharmacokinetic measures, peak plasma concentration (Cmax) and area under the curve (AUC).
ROC curve analysis showed that for predicting preeclampsia, the area under the curve was 0.
Importantly, a recent study has now shown that Lp-PLA(2) may increase the area under the curve beyond that of traditional cardiovascular risk factors and C-reactive protein.
Based on the algorithm, the area under the curve was 0.
The 2-hour glucose levels, insulin area under the curve, and glucose area under the curve were also significantly higher in brothers of women with PCOS.

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