arcitumomab


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arcitumomab

CEA scan Immunology A 99mTc-labelled murine IgG monoclonal Fab fragment which attaches in vivo to CEA and can be used as a tumor marker to detect GI tract CAs using immunoscintigraphy See Monoclonal antibody.
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Several radioimmunoconjugates have been approved for cancer diagnosis, for example, arcitumomab (CEA-scan[R]), a [sup.99m]Tc-labeled antibody fragment used for imaging of colorectal cancer, and capromab pendetide (ProstaScint[R]), an 111 In-labeled mAb directed against prostate specific membrane antigen (PSMA) [78].
A prospective study of 2-[18F] fluoro-2-deoxy-Dglucose/ positron emission tomography scan, 99mTc-labeled arcitumomab (CEA-scan), and blind second-look laparotomy for detecting colon cancer recurrence in patients with increasing carcinoembryonic antigen levels.
(25,26) These have included antibodies for imaging colorectal cancer (eg, satumomab pendetide, (27) arcitumomab (24)), prostate cancer (eg, capromab pendetide (28-30)) NHL, (31) liver cancer, (32) myocardial infarcts (imciromab penlefate (33-35)), infection and inflammation (eg, sulesomab, fanolesomab (36-38)), specific infections, (2) and clots, (39) to mention a few that are now available or in development.