arachidonic acid cascade

ar·a·chi·don·ic ac·id cas·cade

(ă-rak'i-don'ik as'id kas-kād'),
Eicosanoid synthetic pathway.
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The arachidonic acid cascade plays an important role in skin inflammation because it activates cyclooxygenase-2 (COX-2), which leads to the synthesis of substances such as prostaglandins and leukotrienes.
Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis, 29: 371-380.
ASA exerts its anti-aggregatory effect mostly by inhibiting the platelet COX-1 and subsequently thromboxane formation from the arachidonic acid cascade. Aspirin resistance, at molecular level, may be attributed, that is, to changes in efficacy of COX-1 acetylating by ASA [6].
1 Although the phacoemulsification technique has improved greatly over the years, still it involves surgical trauma which predisposes the individual to post-operative inflammation.2 Surgical trauma causes a trigger of the arachidonic acid cascade, which in turn generates prostaglandins by activation of cyclooxygenase (COX) 1 and cyclooxygenase 2.
The arachidonic acid cascade is involved in the masculinizing action of testosterone on embryonic external genitalia in mice.
[PLA.sub.2] is the most upstream enzyme in the arachidonic acid cascade and releases arachidonic acid from the plasma membrane.
The arachidonic acid cascade pathway is responsible for the formation of prostaglandins from the substrate arachidonic acid which is released when cell membrane damage occurs.
It maybe a non-immunoglobulin E (IgE) mediated mechanism with an imbalance in the arachidonic acid cascade, increasing of leukotrienes or bradykinin-mediated.
Orexo also has three significant partnerships with major pharmaceutical companies for research and development programs: discovery stage collaborations with Ortho-McNeil Janssen and Janssen Pharmaceutica in respiratory inflammation and with Boehringer Ingelheim for pain, both within the arachidonic acid cascade and a clinical stage development agreement with Novartis in gastrointestinal disorders.
Nature has adapted fatty acids of vegetable sources such as n-3 and n-6 fatty acids for important cell regulatory functions through the arachidonic acid cascade [11, 12].
Stinging Nettle (Urtica dioica) has been shown to reduce viral infections and components have been shown to block important enzymes within the arachidonic acid cascade as well as having proven their effectiveness in a single ingredient clinical trial.
The inhibition of various enzymes of the arachidonic acid cascade, among these the lipoxygenases and the cyclooxygenases, might be a possible target.