ALOX12

(redirected from arachidonate 12-lipoxygenase)

ALOX12

A gene on chromosome 17p13.1 that encodes a member of the lipoxygenase (LOX) family of non-heme iron dioxygenases, which are involved in the production and metabolism of fatty acid hydroperoxidases.
References in periodicals archive ?
Arachidonate 12-lipoxygenase is localized in neurons, glial cells, and endothelial cells of the canine brain.
These include enzymes for prostaglandin synthesis, such as prostaglandin D2 synthase and prostaglandin-endoperoxide synthase 2 (cyclooxigenase 2, COX2) and enzymes for leukotriene synthesis, such as arachidonate 12-lipoxygenase and arachidonate 15-lipoxygenase.
Arachidonate 15-Lipoxygenases (ALOX15) and Arachidonate 12-Lipoxygenases (ALOX12), members of the LOX family that oxygenate free polyenoic fatty acids, were two key enzymes to synthesize LXA4 [32].