aqueous solubility


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aqueous solubility

The ability of a substance to dissolve in water. The aqueous solubility of a medication determines its ability to be compounded, administered, and absorbed.
See also: solubility
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Therapeutic effectiveness of a drug depends upon the solubility of drug molecules, with low aqueous solubility being regarded as one of the most challenging aspects in the formulation of NCEs.
This approach is fast, broadly applicable due to the aqueous solubility of riboflavin, easily understood, easily applied, facile for use in quality control, and efficient for process monitoring for commercial manufacturing.
For example, therapeutic agents with low aqueous solubility, or ones in which bioactive forms exist in equilibrium with inactive forms, or agents that must be "dribbled in" because they are toxic in high doses.
Various techniques have been employed to enhance the aqueous solubility of poorly water-soluble drugs.
Hydroxypropyl betacyclodextrins are modified [beta]CDs having a higher aqueous solubility (above 60%) and a proven safe profile, especially for parenteral uses.
Distilled water was slowly circulated over the beads for a period of not less than 4 days; the beads were then used to make a Krebs-Ringer solution that contained PCB 153 at the limit of its aqueous solubility (reported as 0.
has yielded aqueous solubility data for over 20,000 compounds in the NIH Molecular Library within the first 90 days of screening and characterization.
However, where a high dose is required--as is the case for many anti-viral and oncology drugs--or if aqueous solubility is particularly low then particle size reduction will have a limited effect on drug uptake, even with nano-sized particles.