Base Pair combines a highly customised
aptamer discovery approach with a patented multiplexing technology, bringing together DNA barcoding and next generation sequencing to enable simultaneous identification of
aptamers that bind up to 30 different targets.
The group is also adapting this system with different
aptamers so that it can sense and regulate the levels of other biomolecules in the body.
This universal process must be standardized for the selection of each target-specific
aptamer by varying the target concentration, the number of rounds, and the stringency of the binding conditions, among others.
2'-F-modified RNA
aptamer (A 10) binding to extracellular domain of PSMA was developed by protein SELEX (10).
Moreover, introducing additional functional groups increases the number of possible contacts between an
aptamer molecule and its target, which results in increased affinity and specificity of an
aptamer, even for complicated non-protein compounds, such as glycated parts of receptors of cells [4, 5].
Aptamer ZE2 and its mutated
aptamer ZE2-mut, were synthesized (Sangon Biotech Co.
Aptamer technology, which has been around for close to 2 decades, provides a platform for generating nucleic acid polymers capable of specific and high-affinity binding to a wide range of molecules.
It then made progress in verifying the effectiveness of its
aptamer technology by developing a biomarker for prostate cancer and an
aptamer for the West Nile virus.
The
aptamers market is classified by geography, application segments and
aptamer type.
If we can use this
aptamer to target the carcinogenic protein, we might be talking about much less radical surgery in the future.
Self-assembly of supramolecular
aptamer structures for optical or electrochemical sensing.
In such assays,
aptamer pairs bind to the target protein to form a sandwich complex fixed onto a micro-plate.
