aprotinin


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Related to aprotinin: Leupeptin

aprotinin

 [ap″ro-ti´nin]
an inhibitor of proteolytic enzymes, used as an antihemorrhagic to reduce perioperative blood loss in patients undergoing cardiopulmonary bypass during coronary artery bypass graft; administered intravenously.

aprotinin

/apro·ti·nin/ (ap″ro-ti´nin) an inhibitor of proteolytic enzymes used to reduce perioperative blood loss in patients undergoing cardiopulmonary bypass during coronary artery bypass graft.

aprotinin

(ā-prōt′n-ĭn, ă-prōt′-)
n.
A polypeptide obtained from bovine lungs that is a protease inhibitor and has been used to reduce bleeding in patients undergoing cardiopulmonary bypass surgery. It was largely withdrawn from the market in 2007 because of safety concerns.

aprotinin

[ap′ro-ti′nin]
an inhibitor of proteolytic enzymes, used as an antihemorrhagic to reduce perioperative blood loss in patients undergoing cardiopulmonary bypass during coronary artery bypass graft; administered intravenously.

aprotinin

A bovine polypeptide and protease inhibitor with antifibrinolytic activity that derives from basic pancreatic trypsin inhibitor (BPTI), which was added to fibrinogen in “fibrin glue”, theoretically enhancing the persistence of the fibrin clot.

It was pulled from the international market in 2007, given the concern that aprotinin increased the risk of complications and death during surgery. In 2012 the European Medicines Agency concluded that the benefits outweighed the risks, and recommended the suspension be lifted.

aprotinin

A drug used in the treatment of bleeding resulting from the excessive breakdown of the fibrin that forms blood clots. An antifibrinolytic. A brand name is Trasylol. In September 2006 the FDA issued a warning that this drug could cause renal failure, congestive heart failure, stroke and death.

aprotinin (āprō´tənin),

n a protease and kallikrein inhibitor useful in the treatment of pancreatitis.

aprotinin

a polyvalent kallikrein-trypsin inhibitor extracted from bovine mast cells; used therapeutically to inhibit fibrinolysis and in the laboratory as a preservative in plasma samples.
References in periodicals archive ?
Macheers for failing to use Amicar or Aprotinin prophylactically.
Such reactions may especially be seen if ARTISS is applied repeatedly over time or in the same setting, or if systemic aprotinin has been administered previously; however, these reactions may also occur in patients receiving ARTISS for the first time.
We collected 2 mL of amniotic fluid into sterile containers containing 5000 kallikrein inhibitor units of aprotinin (0.
The use of aprotinin in cardiac surgery to reduce perioperative bleeding and transfusion is controversial.
Antifibrinolitik ilaclar: Aprotinin ve Tranaxemic acid gibi antifibrinolitik ilaclarin in-vitro etkilerinin ortaya konulmasi in-vivo kullanimlari konusunda yol gostericidir (5).
Millions of patients have been treated with aprotinin or aprotinin-containing hemostats.
Aprotinin is the only product approved for the prevention of perioperative blood loss and of the need for blood transfusion during coronary artery bypass graft surgery.
The reason for the lack of an adverse effect from Tisseel may be that the act of premixing thrombin and aprotinin (component 2) with fibrinogen and factor XIII (component 1) (29) mitigates a direct thrombin effect on the tissue.
The MAX-ACT tubes feature a mixture of diatomaceous earth, kaolin, and glass beads that can be used on all patients, including those on aprotinin.
The multicenter European study of aprotinin, a serine-protease inhibitor that prevents the breakdown of fibrin and other substances involved in coagulation, included 137 patients administered either high-dose or regular-dose aprotinin or placebo during liver transplant surgery.
Protease inhibitors: phenylmethylsulfonylfluoride (PMSF, 20 [[micro]gram]/ml), soybean trypsin inhibitor (20 [[micro]gram]/ml), aprotinin (10 [[micro]gram]/ml), leupeptin (10 [[micro]gram]/ml), bovine [[Alpha].
Request for quotations: Delivery Of The Drug Aprotinin Preparation For 2016