A number of different strategies, including new CPB circuits and components, surgical techniques, and some pharmacologic agents such as glucocorticoids, complement inhibitors and aprotinin
have been employed in attempt to minimize the impact of SIRS on CPB (1,10,12,16).
The CCm-Tf-degrading activity in the samples from IPF patients was not altered by incubation on the CCm-Tf film coated with a mixture of aprotinin
and elastinal (serine proteinase inhibitors) (Figure 5, B), but it was completely abolished in the film coated with a mixture of the serine proteinase inhibitors and 1,10-phenanthroline (a metalloproteinase inhibitor) (Figure 5, C).
Mangano DT, Tudor IC, Dietzel C et al 2006 The risk associated with aprotinin
in cardiac surgery New England Journal of Medicine 354 353-365
Inhibitors of serine proteases like SBTI and aprotinin
strongly inhibited the activity of all enzymes, as did the trypsin inhibitor TLCK (Table 2).
(Trasylol) therapy--is it safe for the kidney?
Successful management of tendinopathy with injections of the MMP-inhibitor aprotinin
. Clin Orthop Relat Res.
Solak, "The cerebroprotective effects of pentoxifylline and aprotinin
during cardiopulmonary bypass in dogs," Perfusion, vol.
modulation of platelet activation in patients undergoing cardiopulmonary bypass operations.
Many strategies have been proposed for reducing intraoperative bleeding including the maintenance of a CVP [less than or equal to] 5 cm of water, reverse Trendelenburg position, systemic infusion of nitroglycerin, and the use of antifibrinolytics agents, recombinant factor Vila, or aprotinin
coli 116,000 Phosphorylase b from rabbit muslce 97,000 Albumin, bovine serum 66,000 Glutamic dehydrogenase from bovine liver 55,000 Ovalbumin from chicken egg 45,000 Glyceraldhyde-3-phosphate- dehydrogenises 36,000 Low range makers Molecular weights (Daltons) Carbonic anhydrase from bovine erythrocytes 29,000 Trypsinogen from bovine erythrocytes 24,000 Trypsin inhibitor from soyabean 20,000 [alpha]-Lactalbumin from bovine milk 14,200 Aprotinin
from bovine lung 6,5000 Table 2: Molecular weights of the L.