Can be pro-inflammatory in CMO, reactivate herpes simplex Apraclonidine
lopidine Sympathomimetics 0.
Half an hour before and just after the SLT application, apraclonidine
1% was administered to prevent IOP spikes.
Contract awarded for Cfq for the supply of apraclonidine
2,4,6) Mechanism Drug Class Preparations of Action Reduction Adrenergic Brimonidine of Aqueous agonists Apraclonidine
Inflow [beta]-blockers Non-selective Timolol Levobunolol Carteolol Selective [beta]-blockers Betaxolol Carbonic Systemic anhydrase Acetazolamide inhibitors Methazolamide Dichlorphenamide Topical Dorzolamide Brinzolamide Increase Cholinergics Pilocarpine in Aqueous Increase Carbachol Outflow trabecular outflow Prostaglandins Latanoprost (xalatan) and other lipid Travoprost (travatan) receptor agonists Increase Bimatoprost (lumigan) uveoscleral Unoprostone outflow Table 2: The Demographic Data of the Patients of POAG Selected for the Study Bimatoprost Timolol Maleate No.
Sympathomimetics (alpha-adrenergic agonists) include apraclonidine
(Iopidine), which has no human eye data, and brimonidine (Alphagan P), which has one case report in pregnancy and breastfeeding showing no fetal or nursing infant harm.
The use of IOP lowering drugs in order to prevent these IOP spikes is mandatory15,16 and prophylactic use of various drugs such as dorzolamide, apraclonidine
, timolol, brimonidine and levobunolol has been documented to reduce the incidence of IOP spikes post Nd:YAG laser capsulotomy8,9.
(Iopidine) is used most often in a higher concentration before and after some kinds of glaucoma laser surgery to prevent or control a rise in eye pressure that is common after the procedure.
9 In the current study, the clinical diagnosis was confirmed by pharmacological testing using topical apraclonidine
Scuderi G et al had used apraclonidine
topically and observed that post-operative IOP was significantly reduced compared to oral acetazolamide or placebo.
5% timolol maleate 1 drop in affected eye 2x/d 1 % apraclonidine
1-2 drops 3x/d 2% pilocarpine 1 drop 4x/d Oral Acetazolamide 500 mg 2x/d Glycerol 50% solution 1-1.
Drug Class How it works Dipivefrin Adrenergics Reduces (Propine); intraocular pressure brimonidine (Alphagan) Apraclonidine
Alpha-2 Decreases intraocular fluid (Lopidine) adrenergics production; increases drainage Betaxolol Beta blockers Decreases (Betoptic) intraocular fluid production Brinzolamide Carbonic Decreases anhydrase intraocular (Azopt) inhibitors fluid production Pilocarpine Cholinergics Increases drainage of (Isopto) intraocular fluid Dorzolomide Combination Decreases beta blocker/ intraocular (Cosopt) carbonic fluid anhydrase production inhibitor Travaprost Prostaglandin Increases analogs drainage of (Travatan) intraocular fluid
These include pholedrine, apraclonidine
, adrenaline and phenylephrine.