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Appendicitis is an inflammation of the appendix, which is the worm-shaped pouch attached to the cecum, the beginning of the large intestine. The appendix has no known function in the body, but it can become diseased. Appendicitis is a medical emergency, and if it is left untreated the appendix may rupture and cause a potentially fatal infection.


Appendicitis is the most common abdominal emergency found in children and young adults. One person in 15 develops appendicitis in his or her lifetime. The incidence is highest among males aged 10-14, and among females aged 15-19. More males than females develop appendicitis between puberty and age 25. It is rare in the elderly and in children under the age of two.
The hallmark symptom of appendicitis is increasingly severe abdominal pain. Since many different conditions can cause abdominal pain, an accurate diagnosis of appendicitis can be difficult. A timely diagnosis is important, however, because a delay can result in perforation, or rupture, of the appendix. When this happens, the infected contents of the appendix spill into the abdomen, potentially causing a serious infection of the abdomen called peritonitis.
Other conditions can have similar symptoms, especially in women. These include pelvic inflammatory disease, ruptured ovarian follicles, ruptured ovarian cysts, tubal pregnancies, and endometriosis. Various forms of stomach upset and bowel inflammation may also mimic appendicitis.
The treatment for acute (sudden, severe) appendicitis is an appendectomy, surgery to remove the appendix. Because of the potential for a life-threatening ruptured appendix, persons suspected of having appendicitis are often taken to surgery before the diagnosis is certain.

Causes and symptoms

The causes of appendicitis are not well understood, but it is believed to occur as a result of one or more of these factors: an obstruction within the appendix, the development of an ulceration (an abnormal change in tissue accompanied by the death of cells) within the appendix, and the invasion of bacteria.
Under these conditions, bacteria may multiply within the appendix. The appendix may become swollen and filled with pus (a fluid formed in infected tissue, consisting of while blood cells and cellular debris), and may eventually rupture. Signs of rupture include the presence of symptoms for more than 24 hours, a fever, a high white blood cell count, and a fast heart rate. Very rarely, the inflammation and symptoms of appendicitis may disappear but recur again later.
The distinguishing symptom of appendicitis is pain beginning around or above the navel. The pain, which may be severe or only achy and uncomfortable, eventually moves into the right lower corner of the abdomen. There, it becomes more steady and more severe, and often increases with movement, coughing, and so forth. The abdomen often becomes rigid and tender to the touch. Increasing rigidity and tenderness indicates an increased likelihood of perforation and peritonitis.
Loss of appetite is very common. Nausea and vomiting may occur in about half of the cases and occasionally there may be constipation or diarrhea. The temperature may be normal or slightly elevated. The presence of a fever may indicate that the appendix has ruptured.


A careful examination is the best way to diagnose appendicitis. It is often difficult even for experienced physicians to distinguish the symptoms of appendicitis from those of other abdominal disorders. Therefore, very specific questioning and a thorough physical examination are crucial. The physician should ask questions, such as where the pain is centered, whether the pain has shifted, and where the pain began. The physician should press on the abdomen to judge the location of the pain and the degree of tenderness.
The typical sequence of symptoms is present in about 50% of cases. In the other half of cases, less typical patterns may be seen, especially in pregnant women, older patients, and infants. In pregnant women, appendicitis is easily masked by the frequent occurrence of mild abdominal pain and nausea from other causes. Elderly patients may feel less pain and tenderness than most patients, thereby delaying diagnosis and treatment, and leading to rupture in 30% of cases. Infants and young children often have diarrhea, vomiting, and fever in addition to pain.
While laboratory tests cannot establish the diagnosis, an increased white cell count may point to appendicitis. Urinalysis may help to rule out a urinary tract infection that can mimic appendicitis.

Key terms

Appendectomy (or appendicectomy) — Surgical removal of the appendix.
Appendix — The worm-shaped pouch attached to the cecum, the beginning of the large intestine.
Laparotomy — Surgical incision into the loin, between the ribs and the pelvis, which offers surgeons a view inside the abdominal cavity.
Peritonitis — Inflammation of the peritoneum, membranes lining the abdominal pelvic wall.
Patients whose symptoms and physical examination are compatible with a diagnosis of appendicitis are usually taken immediately to surgery, where a laparotomy (surgical exploration of the abdomen) is done to confirm the diagnosis. In cases with a questionable diagnosis, other tests, such as a computed tomography scan (CT) may be performed to avoid unnecessary surgery. An ultrasound examination of the abdomen may help to identify an inflamed appendix or other condition that would explain the symptoms. Abdominal x-rays are not of much value except when the appendix has ruptured.
Often, the diagnosis is not certain until an operation is done. To avoid a ruptured appendix, surgery may be recommended without delay if the symptoms point clearly to appendicitis. If the symptoms are not clear, surgery may be postponed until they progress enough to confirm a diagnosis.
When appendicitis is strongly suspected in a woman of child-bearing age, a diagnostic laparoscopy (an examination of the interior of the abdomen) is sometimes recommended before the appendectomy in order to be sure that a gynecological problem, such as a ruptured ovarian cyst, is not causing the pain. In this procedure, a lighted viewing tube is inserted into the abdomen through a small incision around the navel.
A normal appendix is discovered in about 10-20% of patients who undergo laparotomy, because of suspected appendicitis. Sometimes the surgeon will remove a normal appendix as a safeguard against appendicitis in the future. During the surgery, another specific cause for the pain and symptoms of appendicitis is found for about 30% of these patients.


The treatment of appendicitis is an immediate appendectomy. This may be done by opening the abdomen in the standard open appendectomy technique, or through laparoscopy. In laparoscopy, a smaller incision is made through the navel. Both methods can successfully accomplish the removal of the appendix. It is not certain that laparoscopy holds any advantage over open appendectomy. When the appendix has ruptured, patients undergoing a laparoscopic appendectomy may have to be switched to the open appendectomy procedure for the successful management of the rupture. If a ruptured appendix is left untreated, the condition is fatal.


Appendicitis is usually treated successfully by appendectomy. Unless there are complications, the patient should recover without further problems. The mortality rate in cases without complications is less than 0.1%. When an appendix has ruptured, or a severe infection has developed, the likelihood is higher for complications, with slower recovery, or death from disease. There are higher rates of perforation and mortality among children and the elderly.


Appendicitis is probably not preventable, although there is some indication that a diet high in green vegetables and tomatoes may help prevent appendicitis.



Van Der Meer, Antonia. "Do You Know the Warning Signs of Appendicitis?" Parents Magazine (April 1997): 49.


inflammation of the vermiform appendix, a serious disease that usually requires surgical removal (appendectomy). When performed early the operation is comparatively simple and safe. When the appendix becomes inflamed and infected, rupture may occur within a matter of hours. Rupture of the appendix leads to peritonitis, one of the most serious of all diseases, although its danger has been reduced by antibacterial agents.
Cause. If the tubelike appendix becomes plugged by a hard bit of fecal matter or by intestinal worms, or becomes inflamed from other causes, normal drainage cannot take place. Because the appendix is chiefly lymphatic tissue, an infection that produces enlarged lymph nodes elsewhere in the body also can increase the glandular tissue in the appendix and obstruct its lumen. Narrowing of the lumen makes the pouchlike organ more susceptible to bacterial infection. Escherichia coli and other types of bacteria multiply and cause inflammation and infection that spread to the peritoneal cavity unless the body's defenses are able to overcome the infection or the appendix is removed before it ruptures.
Symptoms. The classic symptoms of appendicitis are pain, nausea, vomiting, and low-grade fever in adults. Children tend to have higher fevers. The pain typically begins in the umbilical region and eventually localizes in the right lower quadrant of the abdomen over the site of the appendix. The pain is persistent and is aggravated by motion, causing the patient to bend over and tense the abdominal muscles (muscle guarding). Rebound pain occurs when the abdomen is deeply palpated and the hand is quickly removed from the abdomen. The patient also can feel pain in the area of the appendix when either a rectal or pelvic examination is done.

Other data that may support a diagnosis of appendicitis are obtained through a blood cell count. An elevated white cell count (leukocytosis) commonly accompanies appendicitis as it does other kinds of inflammation. Mild leukocytosis of 14,000 to 16,000 per mm3 is common. A white cell count higher than 20,000 per mm3 suggests a ruptured appendix and peritonitis.

Other diseases that can be mistaken for appendicitis are gallbladder attacks and kidney infection on the right side. The onset of pneumonia, rheumatic fever, or diabetic ketoacidosis can imitate appendicitis. In women, there is the possibility of a ruptured ectopic pregnancy, a twisted ovarian cyst, or a hemorrhaging ovarian follicle at the middle of the menstrual cycle.
Patient Care. When appendicitis is suspected because of symptoms exhibited by the patient, a health care provider should be notified immediately. The patient should lie down and remain as quiet as possible. It is best to give him nothing by mouth, and because of the danger of aggravating the condition and possibly causing rupture of the appendix, cathartics and laxatives are contraindicated. Applications of heat and the administration of laxatives or enemas are contraindicated for the same reasons. After the patient has been assessed and a diagnosis of appendicitis has been established, appendectomy will probably be performed as soon as possible.

During the preoperative phase it may be necessary to hydrate the patient with intravenous fluid therapy, especially when there has been prolonged nausea and vomiting. Decompression of the intestinal contents by suction via a nasogastric tube is also necessary in some cases.

Postoperative care is usually uneventful. The exception is when there has been a ruptured appendix; this serious condition warrants diligent and aggressive nursing care to overcome the effects of peritonitis with the resultant shifting of body fluids, hypovolemia (which can be life-threatening), and septic shock. Antibacterial drugs are administered to combat the infection. Gastric and intestinal decompression is maintained, and most surgeons advocate intraperitoneal draining by means of Penrose drains in order to prevent formation of abscesses and promote healing. The most common complications of appendectomy and peritonitis are (1) infection of the surgical wound, (2) paralytic ileus due to irritation of the small bowel, (3) abscesses, and (4) obstruction and adhesions.

Ongoing assessment of the patient includes observing the type and amount of drainage from the intestinal tract via the nasogastric tube and from the Penrose drain in the wound; appearance of the surgical incision; dressings applied and the frequency with which they are changed; evidence that bowel function is returning to normal, e.g., presence of bowel sounds, passing of flatus and fecal material; measurement of intake and output; tolerance of foods and liquids once the nasogastric tube is removed and decompression discontinued; and tolerance for physical activity, coughing and deep breathing, positioning, and postoperative exercises.


Inflammation of the vermiform appendix.
[appendix + G. -itis, inflammation]


/ap·pen·di·ci·tis/ (ah-pen″dĭ-si´tis) inflammation of the vermiform appendix.
acute appendicitis  appendicitis of acute onset, requiring prompt surgery, and usually marked by pain in the right lower abdominal quadrant, referred rebound tenderness, overlying muscle spasm, and cutaneous hyperesthesia.
chronic appendicitis 
1. that characterized by fibrotic thickening of the organ wall due to previous acute inflammation.
2. formerly, chronic or recurrent pain in the appendiceal area, without evidence of acute inflammation.
fulminating appendicitis  that marked by sudden onset and usually death.
gangrenous appendicitis  that complicated by gangrene of the organ, due to interference of blood supply.
obstructive appendicitis  a common form with obstruction of the lumen, usually by a fecalith.


Inflammation of the vermiform appendix.


Etymology: L, appendere + Gk, itis
an inflammation of the vermiform appendix, usually acute, that, if undiagnosed, leads rapidly to perforation and peritonitis. The inflammation is caused by an obstruction such as a hard mass of feces or a foreign body in the lumen of the appendix, lymphoid hyperplasia, fibrous disease of the intestinal wall, an adhesion, or a parasitic infestation. Appendicitis is most likely to occur in teenagers and young adults and is more prevalent in male patients. One kind of appendicitis is chronic appendicitis.
observations The most common symptom is constant pain in the right lower quadrant of the abdomen around McBurney's point, which the patient describes as having begun as intermittent pain in midabdomen. Rebound tenderness occurs at McBurney's point as well. Pain may also occur on the left side. Extreme tenderness occurs over the right rectus abdominis muscle. To decrease the pain, the patient keeps the knees bent to prevent tension of the abdominal muscles. Appendicitis is characterized by vomiting, a low-grade fever of 99° to 102° F, an elevated white blood cell count, rebound tenderness, a rigid abdomen, and decreased or absent bowel sounds. Other indications of peritonitis include increasing abdominal distension, acute abdomen, tachycardia, rapid and shallow breathing, and restlessness. If peritonitis is suspected, IV antibiotic therapy, fluids, and electrolytes are given.
nursing considerations The nurse is alert to the signs and symptoms of rupture and peritonitis and provides education about the diagnosis, treatment, and recovery.
interventions Treatment is appendectomy within 24 to 48 hours of the first symptoms because delay usually results in rupture and peritonitis as fecal matter is released into the peritoneal cavity. The fever rises sharply once peritonitis begins. The patient may have sudden relief from pain immediately after rupture, followed by increased, diffuse pain.
enlarge picture
Appendicitis: laparoscopic view


Inflammation of the vermiform appendix, most common in children.
Clinical findings
Right lower quadrant pain of acute onset; rebound tenderness over McBurney’s point in right lower quadrant; fever, anorexia, constipation, diarrhoea, nausea, vomiting.
Increased WBCs, left shift of WBCs, increased ESR.
History, physical exam, ultrasound, CT.
Many cases eventually rupture; regression is rare.
Rupture, purulent peritonitis; if untreated, death.


Surgery Inflammation of the vermiform appendix which is most common in children Clinical Right lower quadrant pain of acute onset, rebound tenderness over McBurney's point in right hypogastrium, fever, anorexia, constipation, diarrhea, N&V Lab ↑ WBCs, left shift of WBCs, ↑ ESR Diagnosis Hx, PE, ultrasound, CT Management Appendectomy Complications Rupture, purulent peritonitis; untreated, death. See Appendix. Cf Left-sided appendicitis.


Inflammation of the vermiform appendix.
[appendix + G. -itis, inflammation]


Acute inflammation of the blind-ended ‘vermiform’ APPENDIX. The condition usually starts with central abdominal pain and slight fever. Vomiting may occur. The pain then shifts to the lower right corner of the abdomen and increases in severity. It is made worse by movement or coughing. There is considerable local tenderness and either constipation or slight diarrhoea may occur. The main danger is rupture of an obstructed appendix, release of the contents into the abdominal cavity, and PERITONITIS. Treatment usually involves an operation to remove the inflamed appendix, but conservative management is sometimes appropriate. The diagnosis is not always easy. CT scanning has been found helpful.


Inflammation of the vermiform appendix.
[appendix + G. -itis, inflammation]


inflammation of the vermiform appendix. Occurs in humans and the great apes. The syndrome includes abdominal pain, fever and leukocytosis.

Patient discussion about appendicitis

Q. How is Acute Appendicitis Diagnosed? My doctor sent me to the emergency room because he thought I might have acute appendicitis. What are the symptoms and how is it diagnosed?

A. The symptoms of acute appendicitis can be misleading at first, because they are very unspecific. Usually the patient arrives with abdominal pain, that is "classicaly" located in the lower right side of the abdomen. However, sometimes the pain can't be located at a certain location. The pain tends to increase within hours, and become intolerable, to a point where the patient seeks medical care. Other common symptoms are nausea, vomiting, lack of appetite and fever. The diagnosis is usually made clinically by physical examination. In some cases a CT-scan is performed as well.

Q. What Causes Acute Appendicitis? I've heard that appendicitis is a very common situation. What causes it to happen? Is there a way to avoid it?

A. Appendicitis is caused by an infection of the appendix, usually from bacterias that are already located in the abdomen. It is not a situation that can be avoided and can occur in a high prevalence in the population.

Q. What happens if you leave appendicitis alone? I have symptoms of appendicitis, but I don't want to go to the hospital. What should I do? and what could happen?

A. If you have symptoms of appendicitis you should see a doctor immediately, because the major complication of an untreated appendix is rupture and infection of the entire abdomen, that can lead to generalized sepsis.

More discussions about appendicitis
References in periodicals archive ?
In the said case, the bicycle handlebar had injured the lower abdomen and symptoms started 2 days after the trauma with the diagnosis of perforated suppurative appendicitis in pathological examination.
Although the reasons why colonoscopy increases the risk of appendicitis remain unclear, the article offers some theories, including asking if bacteria within the colon are altered as the bowel is prepared prior to colonoscopy in ways that increase the likelihood of inflammation.
In this article, we present our institution's MR imaging protocol for evaluation of suspected appendicitis in the pregnant patient and illustrate the MR imaging appearance of both the normal appendix and spectrum of appearances of acute appendicitis seen in pregnancy.
Acute appendicitis is one of the most common abdominal surgical emergencies, with a lifetime prevalence of approximately one in seven1.
Keywords: Acute appendicitis, Leucine-rich alpha-2-glycoprotein-1, Abdominal pain, Emergency department.
This study is done to evaluate the association between hyperbilirubinaemia in cases of acute appendicitis and its complications.
In the antibiotic group, 186 of 256 patients (70%) treated with antibiotics did not require surgery; 70 (27%) underwent appendectomy within 1 year of initial presentation for appendicitis (JAMA.
Histopathologically, acute appendicitis was detected in 125 (80.
A raised CRP in appendicitis has not only been shown to be a good predictor of appendicitis but is also directly related to the severity of the inflammation.
Pericecal inflammation, abscess formation, fluid in the right iliac fossa, cecal wall thickening, and an ileocecal mass may be CT findings in SA, which are similar to those in acute appendicitis.
sup][5] Although patients in the known setting of AML who develop abdominal pain after receiving chemotherapy are often found to have suppurative appendicitis after surgical intervention, acute leukemic appendicitis as the initial manifestation of AML proven on pathological review is even rarer,[sup][3],[4] and early recognition is difficult, especially when there is no obvious blasts in the peripheral blood like our case.
Patients: A retrospective chart review was carried out on patients who underwent SILA for acute appendicitis from June 2012 to August 2015 at the Ehime Rosai Hospital in Niihama, Japan and Saiseikai Shimonoseki General Hospital in Shimonoseki, Japan.