APAF1

(redirected from apoptotic protease-activating factor 1)

APAF1

A gene on chromosome 12q23.1 that encodes a cytoplasmic protein, which initiates apoptosis. Apoptotic peptidase-activating factor 1 contains several copies of the WD-40 domain, a caspase recruitment domain (CARD) and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, APAF-1 forms an oligomeric apoptosome, which binds and cleaves caspase-9 preproprotein, releasing the activated form, which stimulates the caspase cascade that commits the cell to apoptosis.
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We also identified related proteins in cell death and apoptosis, such as apoptotic protease-activating factor 1 (APAF_RAT, 780.9-folds), programmed cell death protein 10 (PDC10_RAT, 233.2-folds), galectin-1 (LEG1_RAT, 1.75-folds), and programmed cell death 6-interacting protein (PDC6I_RAT).
Cytochrome c then associates with apoptotic protease-activating factor 1 (APAF-1) and caspase-9 to form a complex called the apoptosome.