APAF1

(redirected from apoptotic peptidase activating factor 1)

APAF1

A gene on chromosome 12q23.1 that encodes a cytoplasmic protein, which initiates apoptosis. Apoptotic peptidase-activating factor 1 contains several copies of the WD-40 domain, a caspase recruitment domain (CARD) and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, APAF-1 forms an oligomeric apoptosome, which binds and cleaves caspase-9 preproprotein, releasing the activated form, which stimulates the caspase cascade that commits the cell to apoptosis.
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Gene ID Gene symbol Gene description 78963 Apaf1 Apoptotic peptidase activating factor 1 288227 Bace2 Beta-site APP-cleaving enzyme 2 25031 Plcb4 Phospholipase c, beta 4 Gene ID [log.sub.2] (ratio) P value 78963 -1.0464 0.00267 288227 -1.0448 0.00001 25031 -1.0673 0.00381 FIGURE 3: The results of GO classification in ME pretreatment group.
[4] Human genes: APAF1, apoptotic peptidase activating factor 1; MAP2K4, mitogen-activated protein kinase kinase 4; TP53, tumor protein p53; DLC1, deleted in liver cancer 1; NMT1, N-myristoyltransferase 1; EF2S1, eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; DYNLL1, dynein, light chain, LC8-type 1.

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