It decreased phosphorylation of signal transducer and activator of transcription (STAT3/5) proteins, inhibited cell proliferation and induced apoptotic cell
death in cell models expressing mutationally active JAK2 or FLT3.
death has been demonstrated as the main mechanism of germ-cell loss in the perinatal period.
In one model; the main role of the P53 pathway in determining cell destiny has been suggested either to activate the control points in the cell cycle or facilitate repair, thereby increasing survival or, inducing apoptotic cell
death was determined using annexin-V-fluorescein isothiocyanate (FITC)/7-amino-actinomycin D (7-AAD; BD Biosciences) and Cycletest[TM] Plus DNA Reagent Kit (BD Biosciences) in all cells.
"Metformin also induced endoplasmic reticulum stress and subsequent apoptotic cell
death via the activation the proapoptotic family members," she said.
Mouse primary ESCs of different passages (passage 4 or 19) were employed and cell proliferation, mitochondrial ATP production, reactive oxygen species (ROS) generation, and apoptotic cell
numbers of the ESCs were monitored after being post-thaw subcultured different times.
They exhibit decreased apoptotic cell
death, compared with normal skin.
Having tools to study DNA damage and the apoptotic cell
process is an important aspect of understanding drug action.
Caspases are proteases which play critical role in the initiation and execution of apoptotic cell
Approaches in activating NRF2, such as administration of the NRF2 activator sulforaphane (SFN) [5, 6], supplementation of zinc , and exposure to low-dose X-irradiation , effectively ameliorated diabetes-induced testicular inflammation, ER stress, and apoptotic cell
death, in rodent models of both type 1 and type 2 diabetes.
In conclusion, our results showed that the Spatholobus suberectus column extract (SSCE) induced apoptotic cell
cycle arrest of MCF-7 cells, inhibited activity of nucleus p-ER[alpha] and p-ER[beta], and downregulated the expression of p-ER[alpha], which resulted in suppression of the MAPK PI3K/AKT pathway.
Oh et al., "Inhibition of inflammation and oxidative stress by Angelica dahuricae radix extract decreases apoptotic cell
death and improves functional recovery after spinal cord injury," Journal of Neuroscience Research, vol.