apoptosome


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apoptosome

(ă-pop'tō-sōm),
A heptameric apoptotic protease activating factor 1 (Apaf-1)-cytochrome-c complex. The apoptosome recruits and activates caspases that cleave intracellular substrates and ultimately lead to cell death by apoptosis. Release of mitochondrial cytochrome-c into the cytoplasm results in binding with monomers of Apaf-1, thereby inducing a conformational change that permits a stable association with (deoxy)adenosine triphosphate and formation of the heptameric complex.
See also: apoptosis.
[apoptosis + -some]
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References in periodicals archive ?
A suggested mechanism by which autophagy inhibits apoptosis is the sequestration of mitochondria damaged by the autophagosome, thus preventing the released mitochondrial cytochrome c to form a functional apoptosome in the cytoplasm (53).
Regulation of the Apaf-1-caspase-9 apoptosome. J Cell Sci 2010; 123: 3209-3214, doi: 10.1242/ jcs.073643.
The released cytochrome c interacts with apoptotic protease-activating factor 1 and forms an apoptosome that activates caspase 9, leading to the activation of downstream caspases 3 and 7 and the apoptotic death response [39-42].
Cytochrome c activates procaspase 9, resulting in formation of the apoptosome [26].
Rehm, "A systems biology analysis of apoptosome formation and apoptosis execution supports allosteric procaspase-9 activation," The Journal of Biological Chemistry, vol.
Briefly, the interaction between HK2 and voltage-dependent anion channel (VDAC1) reduces the release of proapoptotic proteins and prevents cancer cells from undergoing apoptosis [87]; phosphoglucose isomerase exerts its antiapoptosis effect by suppressing the expression of Apaf-1 and caspase-9 genes, thereby indirectly regulating the formation of the apoptosome [88, 89].
A molecular view on signal transduction by the apoptosome. Cell Signal 2012; 24: 1420-5.
In general, intrinsic apoptosis is a mitochondrion-centered cell death that is mediated by mitochondrial outer membrane permeabilization, and results in apoptosome formation, activation of caspase-9, and subsequent activation of effector caspases.
Salvesen, "The apoptosome: signalling platform of cell death," Nature Reviews Molecular Cell Biology, vol.
The Cyt c forms a complex with procaspase-9 and Apaf-1 and stimulates the formation of apoptosome that further activate caspase-9.
When cytochrome c accumulates in the cytosol, it complexes with procaspase-9 and Apaf-1 to form the "apoptosome", which in turn activates caspase-3 (Figure 2) [6].

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