apoptosome


Also found in: Wikipedia.

apoptosome

(ă-pop'tō-sōm),
A heptameric apoptotic protease activating factor 1 (Apaf-1)-cytochrome-c complex. The apoptosome recruits and activates caspases that cleave intracellular substrates and ultimately lead to cell death by apoptosis. Release of mitochondrial cytochrome-c into the cytoplasm results in binding with monomers of Apaf-1, thereby inducing a conformational change that permits a stable association with (deoxy)adenosine triphosphate and formation of the heptameric complex.
See also: apoptosis.
[apoptosis + -some]
Mentioned in ?
References in periodicals archive ?
A molecular view on signal transduction by the apoptosome.
Recent advances in diagnostic and prognostic aspects of acute myeloid leukaemia
In general, intrinsic apoptosis is a mitochondrion-centered cell death that is mediated by mitochondrial outer membrane permeabilization, and results in apoptosome formation, activation of caspase-9, and subsequent activation of effector caspases.
PM[sub]2.5 Exposure Elicits Oxidative Stress Responses and Mitochondrial Apoptosis Pathway Activation in HaCaT Keratinocytes
Cytochrome c assembles APAF-1 and procaspase-9 to form apoptosome, inducing apoptosis.
Apoptotic effect of eugenol envolves G2/M phase abrogation accompanied by mitochondrial damage and clastogenic effect on cancer cell in vitro
Consequently, pores are formed to leak the components of apoptosome from mitochondrial intermembrane space [93].
Killing Me Softly: Connotations to Unfolded Protein Response and Oxidative Stress in Alzheimer's Disease
Scientists from Australia, Europe, the US, and Canada address the biochemical and morphological changes that occur during apoptosis, autophagy, necrosis, and other forms of cell death, and provide 69 protocols that use flow cytometry, imaging and microscopy, RNAi, western blotting, enzymatic activity measurements, and other tools to assess DNA fragmentation, lysosomal membrane permeabilization, autophagic flux, apoptosome or ripotosome formation, caspase activation, and cytochrome c release for in vitro systems and in vivo models, including mice, C.
Cell Death Techniques: A Laboratory Manual
HSP70 blocks apoptosis by binding apoptosis activating factor-1 (Apaf-1), thereby preventing the formation of the apoptosome complex (Ravagnan et al.
Expresion diferencial de genes en Pyropia columbina (Bangiales, Rhodophyta) bajo hidratacion y desecacion natural
Cytochrome c recruits Apaf-1 and pro-caspase-9 to compose the apoptosome, which triggers a caspase 9/3 signaling cascade, culminating in apoptosis.
Pathology of cell death
Cytochrome C combines with apoptosis activating factor 1 and the initiator caspase-9, to form apoptosome.
Is suppression of apoptosis a new therapeutic target in sepsis?
Once assembled, the apoptosome processes and activates procaspase-9 as the initiator caspase, which in turn proteolytically activates the executioner procaspase-3 and procaspase-7.
The effect of intravitreal bevacizumab on apoptosis of rat retina cells/Intravitreal bevacizumabm sican retina hucrelerinde apoptozis uzerine etkileri
Physiological and pathological roles of Apaf1 and the apoptosome.
Expresion de TRF2 y GAPDH en el envejecimiento de las celulas del epitelio superficial del ovario in vitro
The mitochondrion plays an important role in apoptosis through the release of cytochrome c, the formation of an apoptosome, and subsequent activation of caspases (27), as well as through caspase independent mechanisms.
How genetics and environment contribute to athletic prowess and compensation for disease deficiencies
2000) Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome.
Effects of age increment and 36-week exercise training on antioxidant enzymes and apoptosis in rat heart tissue

Medical browser ?
Full browser ?