MAP3K5

(redirected from apoptosis signal regulating kinase 1)

MAP3K5

A gene on chromosome 6q22.33 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K5 activates the P38 and JNK MAPK pathways in response to various signals, including calcium and GPCR signalling and endoplasmic
reticulum stress. It is highly expressed in the heart and pancreas.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
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2007) Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death-associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson's disease: protection by [alpha]-lipoic acid.
2005) Enhanced TNF-[alpha]induced apoptosis in Fanconi anemia type Cdeficient cells is dependent on apoptosis signal regulating kinase 1.

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