BIRC2

(redirected from apoptosis inhibitor 1)

BIRC2

A gene on chromosome 11q22 that encodes a protein which inhibits apoptosis by binding to tumour necrosis factor-receptor-associated factors TRAF1 and TRAF2, interfering with activation of ICE-like proteases.
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Cytokine-induced apoptosis inhibitor 1 (CIAPIN1) is a newly identified anti-apoptotic protein that has no homology with Bcl-2, caspase, and IAP families or signal-transduction molecules that regulate apoptosis (9).
A new apoptosis inhibitor, CIAPIN1 (cytokine-induced apoptosis inhibitor 1), mediates multidrug resistance in leukemia cells by regulating MDR-1, Bcl-2, and Bax.

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