CASP3

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CASP3

A gene on chromosome 4q34 that encodes a so-called effector caspase belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of apoptosis, as well as various stages of embryological development. CASP3 is highly expressed in the lung, spleen, heart, liver and kidney.
References in periodicals archive ?
Immunohistochemistry was performed using primary antibodies against Caspase 3 (apopain, SCA-1, Yama, and CPP32 US Biological, USA) and anti-inducible nitric oxide synthase (anti-iNOS) (isoform Nitros Oxide) (dilution 1: 50; Santa Cruz Biotechnology) using streptavidin-biotin immunoperoxidase technique (DakoCytomation, California, USA).
Caspase-3 also known as CPP32 (32 kDa cysteine protease) or apopain is a cysteine protease with aspartate specificity and a well-characterized effector of apoptosis.
The roles of Bcl-XL and apopain in the control of erythropoiesis by erythropoietin.