Sunovion's NDA submission is supported by a 12-week, randomized, double-blind, placebo-controlled, parallel group Phase 3 study, CTH-300, in which apomorphine
sublingual film demonstrated superior efficacy versus placebo for the on-demand treatment of OFF episodes associated with PD, with the effect persisting until the last observed time point at 90 minutes.
Figure 13 illustrates four different brain states in a single scheme of the lesioned hemisphere in the hemiparkinsonian rat: the healthy brain, the effects of a lesion, DBS after lesioning, and apomorphine
administration after lesioning.
Scores on the Unified Parkinson's Disease Rating Scale motor score at 20, 40, and 90 minutes were significantly better in the apomorphine
Recovery of erectile function by oral administration of apomorphine
. Urology, 45, 200-206.
has released topline results from its Phase 3 clinical trial, CTH-300, that evaluated apomorphine
sublingual film (APL-130277) in patients with Parkinson's disease who experience motor fluctuations (OFF episodes), the company said.
Different effects of levodopa and apomorphine
on blink reflex recovery cycle in essential blepharospasm.
M2 PHARMA-September 13, 2018-Health Canada Accepts of New Drug Submission for Apomorphine
In cases of food bloat, induction of vomiting is best left to the discretion and experience of veterinary professionals, who can use an injectable medication (usually apomorphine
) to quickly and more safely induce vomiting.
The hospital had recently provided treatment with Apomorphine
or Duodopa pumps, that injects the medicine through tube at the intestine and the second injects the medicine through a needle taken under the skin, he said.
The efficacy of the 6-OHDA lesion was evaluated with apomorphine
test (0.05 mg/kg, 1 ml/kg, S.C.) in all rats 3 weeks after the surgery.
is a nonspesific agonist of both dopamine D1 and D2 receptors, and it generates climbing behavior in rodents (13).
Contrary to the minor interest of [sup.18]F-FDG in AD therapeutic assessment, a recent study has shown that apomorphine
pump seems to be an interesting option for treating advanced PD patients in therapeutic impasse, thanks to a brain glucose metabolism study .