apolipoprotein E


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Related to apolipoprotein E: apolipoprotein E deficiency

ap·o·lip·o·pro·tein E

an apolipoprotein found in several plasma lipoprotein particles including chylomicrons, VLDL, and HDL. Three major isoforms are encoded by three common alleles at the Apo E locus: E2, E2, and E4. The E2 allele is associated with lower total plasma cholesterol and LDL cholesterol than is E3, whereas E4 is associated with higher LDL and total cholesterol than E3.

APOE

A gene on chromosome 19q13.2 that encodes apolipoprotein E, the main apoprotein of chylomicrons, which binds to a specific receptor on liver cells and peripheral cells. ApoE mediates binding, internalisation and catabolism of lipoprotein particles and serves as a ligand for the LDL (apo B/E) receptor.

Molecular pathology
APOE mutations cause hyperlipoproteinaemia type III (familial dysbetalipoproteinaemia), which is characterised by increased plasma cholesterol and triglycerides due to impaired chylomicron and VLDL remnant clearance.

apolipoprotein E

A 34-kD cholesterol-binding glycoprotein, which comprises 15% of VLDL; apoE maps to chromosome 19, is secreted by macrophages that mediate the uptake of lipoproteins–VLDL, HDL, LDL and cholesterol esters into cells via distinct binding domains for each receptor; apo-E has a central role in the metabolism of TG-rich lipoproteins, and mediates the uptake of chylomicrons and VLDL by the liver
References in periodicals archive ?
Apolipoprotein E phenotypes, dementia and mortality in a prospective population sample.
Rapid determination of apolipoprotein E genotype using a heteroduplex generator.
Hofman et al., "Apolipoprotein E gene is related to mortality only in normal weight individuals: the Rotterdam Study," European Journal of Epidemiology, vol.
Modulation of apolipoprotein D and apolipoprotein E expression in rat hippocampus after entorhinal cortex lesion.
Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease.
Apolipoprotein E: Structure-function relationships.
Having the apolipoprotein E [epsilon]4 allele was the second-best predictor, with an odds ratio of 9.2, compared with those without the Alzheimer's disease-associated gene, he said.
The 121 individuals possessing at least one copy of a specific variant of the apolipoprotein E gene, which influences brain-cell repair, performed as well as the rest at age 11.
Also not well understood is the mechanism that underlies the link between the epsilon4 allele of the apolipoprotein E gene and Alzheimer's disease (AD).