apolipoprotein C3


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apolipoprotein C3

An 8.7-kD protein and major constituent of chylomicrons and VLDL. Apolipoprotein C3 is a cofactor for sphingomyelinase, an inhibitor of lipoprotein lipase; it may activate lecithin:cholesterol acyltransferase and modulate uptake of TG-rich remnants by hepatic receptors.
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Drugs such as pemfibrate, angiopoietin-like protein 3 (ANGPTL3) inhibitors, apolipoprotein C3 (apo C3) inhibitors and diacylglycerol acyltransferase-1 (DGAT 1) inhibitors have shown promising results in the management of hypertriglyceridaemia.
Many later genetic studies have confirmed these findings, including one of our own demonstrating that APOC3 (apolipoprotein C3) loss-of-function heterozygosity led to lifelong low triglycerides and consequently reduced ischemic cardiovascular disease (2, 6).
Genetic effect of two polymorphisms in the apolipoprotein A5 gene and apolipoprotein C3 gene on serum lipids and lipoproteins levels in a Chinese population.