apolipoprotein C-III

ap·o·lip·o·pro·tein C-III

an apolipoprotein found in VLDL, HDL, and chylomicrons. It inhibits several lipases, including lipoprotein lipase.


A gene on chromosome 11q23.1-q23.2 that encodes apolipoprotein C-III, a very low-density lipoprotein (VLDL) protein that inhibits lipoprotein and hepatic lipases; it is thought to delay catabolism of triglyceride-rich particles.

apolipoprotein C-III

An 8.7 kD protein and major constituent of chylomicrons and VLDL; it is a cofactor for sphingomyelinase, an inhibitor of lipoprotein lipase, may activate lecithin; cholesterol acyltransferase and modulate uptake of TG-rich remnants by hepatic receptors; Pts with apoC-III deficiency have an ↑ risk of CAD
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The study by Harvard School of Public Health (HSPH) researchers is the first research to show that a small protein, apolipoprotein C-III (apoC-III), that sometimes resides on the surface of HDL cholesterol may increase the risk of heart disease and that HDL cholesterol without this protein may be especially heart protective.
Plasma apolipoprotein C-III transport in centrally obese men: associations with very low-density lipoprotein apolipoprotein B and high-density lipoprotein apolipoprotein A-I metabolism.
Other atherogenic lipoprotein particles, including chylomicron and VLDL remnants, abnormal remnant composition, and increased apolipoprotein C-III complicate the metabolic syndrome picture as well, said Dr.
Rx] garnered average reductions of up to 71% in apolipoprotein C-III (apoC-III) and up to 64% in triglycerides, and average increases of up to 52% in high-density lipoprotein cholesterol (HDL-C), the 'good' cholesterol.
Rx] achieved average reductions of up to 71 percent in apolipoprotein C-III (apoC-III) and up to 64 percent in triglycerides, and average increases of up to 52 percent in high-density lipoprotein cholesterol (HDL-C), the 'good' cholesterol.
Of the 18 differentially displayed proteins, 12 proteins (a-1B-glycoprotein, keratin type II, neurofilament triplet L protein, vitamin D-binding protein precursor, protease C1 inhibitor precursor, keratin type I cytoskeleton, complement factor B, complement C1r subcomponent precursor, transthyretin precursor, zinc finger protein 792, kininogen-1 precursor, and PRAME family member 7) decreased in concentration after TCC exercise; 4 proteins (complement factor H, apolipoprotein C-III precursor, complement C3 precursor, and [[alpha].
Poster #141 Alexander V, An antisense inhibitor of apolipoprotein C-III significantly decreases apolipoprotein C-III, triglycerides, Very-Low-Density Lipoprotein cholesterol and particle number, and increases High-Density Lipoprotein cholesterol and particle number in hypertriglyceridemic patients on a fibrate.
Apolipoprotein B-100 kinetics in visceral obesity: associations with plasma apolipoprotein C-III concentration.
In a Phase 1 trial, CAT-2003 demonstrated significant reductions in fasting and post-prandial triglyceride levels and had positive effects on lipid biomarkers including reductions in LDL, apolipoprotein C-III (ApoC-III), ApoB and PCSK9.
Apolipoprotein C-III (apoC-III) resides on the surface of triglyceride-rich lipoproteins (2) but is also present on HDL particles (3) and remnant-like particles (4).
Rx] as a monotherapy and achieved statistically significant mean reductions of up to 80 percent in apolipoprotein C-III (apoC-III) and up to 71 percent in triglycerides.