apolipoprotein C-I

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ap·o·lip·o·pro·tein C-I

an apolipoprotein found in VLDL and chylomicrons. It modulates the interaction of apolipoprotein E with VLDL.
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 19q13.2 that encodes a member of the apolipoprotein C1 family expressed primarily in the liver and activated when monocytes differentiate into macrophages. APOC1 is thought to modulate the interaction of APOE with beta-migrating VLDL and inhibit beta-VLDL binding to the LDL-receptor-related protein. It binds free fatty acids and reduces their intracellular esterification.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
An enzyme-linked immunosorbent assay (ELISA) was performed to determine the Apo C-I levels in the serum samples from the two groups, using the Human Apolipoprotein C-I ELISA Kit (Assaypro LLC, MO, USA) according to the manufacturer's instructions.
Major peaks are observed corresponding to IgG, albumin dimer, transferrin, albumin, doubly charged albumin, apolipoprotein A-I, transthyretin, apolipoprotein C-III, apolipoprotein C-II, and apolipoprotein C-I. Serum or plasma must be diluted for this analysis to provide an adequate ratio of matrix to protein.
Ultrafiltrates of plasma have been recognized for several years to contain complex mixtures of thousands of peptides (70) that are smaller than apolipoprotein C-I, the smallest major plasma protein.