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The primary activity of apolipoprotein C is to activate lipoprotein lipase (LPL) leading to lipolysis of TG.
The other apolipoproteins were discovered by separation of the proteins after delipidation of plasma lipoproteins--initially classified as apolipoprotein A if present in [alpha]-lipoproteins (HDL), apolipoprotein B if in [beta]-lipoproteins (LDL), and apolipoprotein C if in pre-[beta]-lipoprotein (VLDL) (27).
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