apolipoprotein B-48

ap·o·lip·o·pro·tein B-48

an apolipoprotein found in chylomicrons and chylomicron remnants. Retained in the intestines of patients with chylomicron retention disease.

apolipoprotein B-48

A 250 kD protein that is a major chylomicron component synthesized in the intestine; ApoB-48 has an obligatory role in the synthesis of chylomicrons and is essential for intestinal absorption of dietary fats and fat-soluble vitamins
References in periodicals archive ?
A more recent study showed that n-3 fatty acids decreased postprandial apolipoprotein B-48 concentrations by 22% suggesting that the reduction in postprandial lipemia with n-3 fatty acids are also related to improvements in chylomicron metabolism [28].
This method assumes that the retinyl ester remains associated with apolipoprotein B-48 and does not exchange with other lipoproteins.
In human plasma apolipoprotein B occurs in two forms apolipoprotein B-100 and apolipoprotein B-48, which are derived from a single gene [39-43] on the short arm of chromosome 2.
Biosynthesis of apolipoprotein B-48 containing lipoproteins: regulation by novel posttranscriptional mechanism.
Objective: This study aimed to investigate effects of chronic black tea consumption on concentrations of chylomicrons and chylomicron remnants using plasma concentrations of apolipoprotein B-48 as a marker.
Main outcome measures: Plasma apolipoprotein B-48, lathosterol, and serum lipid measurements were taken from fasting blood samples at the end of each four-week period.
Effects of intensive atorvastatin and rosuvastatin treatment on apolipoprotein B-48 and remnant lipoprotein cholesterol levels.
Apolipoprotein B-48: comparison of fasting concentrations measured in normolipidaemic individuals using SDS-PAGE, immunoblotting and ELISA.
Triglyceride-rich RLPs are formed in the circulation when chylomicrons of intestinal origin [with apolipoprotein B-48 (apo B-48)] and VLDL of hepatic origin (with apo B-100) are converted by lipoprotein lipase (and to a lesser extent by hepatic lipase) into smaller and more dense particles.
Postprandial chylomicron response may be predicted by a single measurement of plasma apolipoprotein B-48 in the fasting state.
Apolipoprotein B-48 (apoB-48) [4] is an excellent marker of postprandial lipoproteins because it is associated exclusively in humans with intestinally derived chylomicrons (CMs) and their remnants, circulating particles that have been described as atherogenic (1).
A novel antiserum specific to apolipoprotein B-48 application in the investigation of postprandial lipidaemia in humans.