apolipoprotein B-100

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ap·o·lip·o·pro·tein B-100

an apolipoprotein found in LDL, VLDL, and IDL. The ligand for the LDL receptor; absent in certain types of abetalipoproteinemia.
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 2p24-p23 that encodes apolipoprotein B, the main apoliprotein of chylomicrons and low-density lipoproteins, which appears in plasma as two main isoforms: apoB48 (which is synthesised exclusively in the gut) and apoB100 (which is synthesised in the liver).

Molecular pathology
APOB mutations cause hypobetalipoproteinaemia, normotriglyceridemic hypobetalipoproteinaemia, and hypercholesterolaemia due to ligand-defective apoB.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

apolipoprotein B-100

A 550 kD protein synthesized in the liver that is the major component in lipoproteins of endogenous origin–LDL, VLDL, IDL, provides the recognition signal targeting LDL to the LDL–apoB, E receptor and is considered to be the l'enfant terrible of ASHD Ref range 40 to 125 mg/dl Abnormal values ↑ in familial combined hyperlipidemia, acquired hyperlipidemia, in acute angina and MI
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Mipomersen, an oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: Results of 4 phase 3 trials.
This protein is apolipoprotein B-100 (apoB-100) and was completely sequenced for the first time in 1986 by several labs thanks to genetic investigations [22-25].
We investigated the potential role and mechanism of action of an indole-based compound, indole-3-carbinol (I3C), on apolipoprotein B-100 (apoB) production using HepG2 cells.
In human plasma apolipoprotein B occurs in two forms apolipoprotein B-100 and apolipoprotein B-48, which are derived from a single gene [39-43] on the short arm of chromosome 2.
Upon conversion, cholesterol and apolipoprotein B-100 become the predominant components of LDLs and apolipoprotein B-100 is the biological marker that allows LDLs to bind to cellular receptors.
Lipoprotein(a) [Lp(a)], first described by Berg in 1963, is a plasma lipoprotein consisting of a cholesterol-rich LDL particle with one molecule of apolipoprotein B-100 and a molecule of apolipoprotein A [1].
Mipomersen, formerly ISIS 301012, is a lipid-lowering drug targeting apolipoprotein B-100. Currently in phase 3 development, mipomersen has been shown in phase 2 trials to reduce cholesterol and other atherogenic lipids more than 40 percent beyond reductions achieved with current standard lipid-lowering drugs, enabling more patients to achieve lipid targets.
In a cross-sectional analysis of apparently healthy women aged 45 years and older who were followed for 10 years, the women with any history of migraine had small but statistically significant increased total cholesterol, non-HDL cholesterol, apolipoprotein B-100, and C-reactive protein (CRP) levels, compared with women who had no history of migraine, reported Dr.
The analysis also showed that the ratio of total cholesterol to HDL cholesterol was at least as good for predicting the risk of the ocurrence of cardiovascular events as was the ratio of apolipoprotein B-100 to HDL lipoprotein cholesterol (JAMA 2005;294:326-33).
From this triglyceride, the liver makes VLDL, consisting of a rich triglyceride core and an outer surface made of free cholesterol, phospholipids, apolipoprotein B-100 (apoB-100), and apo-E (Guyton & Hall, 2000; Tulenko & Sumner, 2002).
There were no significant changes in serum total cholesterol, triglyceride, LDL-cholesterol, HDL-cholesterol or apolipoprotein B-100 concentrations with black tea ingestion.