APOA5

(redirected from apolipoprotein A-V)

APOA5

A gene on chromosome 11q23 that encodes apolipoprotein A-V, a minor apolipoprotein mainly associated with high-density lipoprotein (HDL), less so with VLDL and chylomicrons. It is an important determinant of plasma triglyceride (TG) levels, both stimulating TG hydrolysis by apo-CII lipoprotein lipase and inhibiting VLDL-TG production.
References in periodicals archive ?
Kuivenhoven et al., "Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study," Journal of Lipid Research, vol.
Hyperlipidemia, and more importantly, hypertriglyceridemia in HIV patients is highly influenced by genetic variability (7) and, among the candidate genes, the newly identified apolipoprotein A-V (APOA5) [1] has emerged as probably the most potent modulator of triglyceride (TG) [2] metabolism.
Inherited apolipoprotein A-V deficiency in severe hypertriglyceridemia.
Structure and interfacial properties of human apolipoprotein A-V. J Biol Chem 2003;278:34438-44.
Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration.
Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice.
A sandwich enzyme-linked immunosorbent assay for human plasma apolipoprotein A-V concentration.
(30.) van der Vliet HN, Sammels MG, Leegwater AC, Levels JH, Reitsma PH, Boers W, et al Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration.
Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren.
New apolipoprotein A-V: comparative genomics meets metabolism.
Apolipoprotein A-V. A novel apolipoprotein associated with an early phase of liver regeneration.