apolipoprotein A-IV

ap·o·lip·o·pro·tein A-IV

an apolipoprotein secreted with chylomicrons and also found in HDL. It participates in the catabolism of chylomicrons and VLDL. It is also required for activation of lipoprotein lipase and LCAT.
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 11q23 that encodes apolipoprotein A-IV, which is a major component of high-density lipoprotein (HDL) and chylomicrons. It plays a role in chylomicrons and VLDL secretion and catabolism, and is required for efficient activation of lipoprotein lipase by ApoC-II. It is a potent activator of lecithin-cholesterol acyltransferase (LCAT).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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Apolipoprotein A-IV (apoA-IV) is an important component of "good" HDL cholesterol.
A protein in blood plasma called apolipoprotein A-IV (ApoA-IV) has been shown to keep platelets in blood plasma from clumping together.
Apolipoprotein A-IV, known as ApoA-IV, is a plasma protein.
The eight differentially expressed proteins included third party data (TPA): vitamin D-binding protein precursor (GC), complement C4 precursor (C4), paraoxonase 1 (PONI), A2M, endopin 1 (EN1), TPA: apolipoprotein A-IV precursor (APOA4), alpha-1-antitrypsin, and haptoglobin (HP).
In our quantification analysis (Figure 3), 15 proteins (amyloid-like protein 2, APLP2; apolipoprotein A-IV, APOA4; beta-2-glycoprotein 1, APOH; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, B3GNT1; complements C4-B, C4B; complements C5, C5; complement components C7, C7; monocyte differentiation antigens CD14, CD14; clusterin, CLU; fibronectin, FN1; gelsolin, GSN; inter-alpha-trypsin inhibitor heavy chain H2, ITIH2; keratin type II cytoskeletal 1, KRT1; pigment epithelium-derived factor, SERPINF1; and vitronectin, VTN) were significantly differentially expressed either in the No DR versus Mi NPDR (AUC value > 0.7) or in the No DR versus Mo NPDR (AUC value > 0.7) comparisons.
Identified proteins with expression that decreased with As exposure (higher intensity in the control gel or absent in the As-treated gel) were RAGE, glutathione-S-transferase (GST)-omega-1, contraspin (a serine--or cysteine--proteinase inhibitor isoform), apolipoprotein A-IV, and apolipoprotein A-I.
Patrick Tso, PhD, professor in the UC Department of Pathology and Laboratory Medicine, has revealed that apolipoprotein A-IV (apoA-IV) is secreted by the small intestine in response to fat absorption.
Genes involved in fatty acid synthesis, such as acetyl-CoA-carboxylase and elongation of long-chain fatty acids were reduced only by PCB-77 in corn-oil--fed mice, whereas lipid transport/export genes such as fatty acid binding protein 2 and 4, ATP-binding cassette A1, and apolipoprotein A-IV were altered in olive-oil--fed mice in response to PCBs.
Apolipoprotein A-IV (apo A-IV) is a 46-kDa plasma protein (1) with different isoforms (2).
Human Apolipoprotein A-IV binds to apolipoprotein A-I/A-II receptor sites and promotes cholesterol efflux from adipose cells.