apolipoprotein A-IV

ap·o·lip·o·pro·tein A-IV

an apolipoprotein secreted with chylomicrons and also found in HDL. It participates in the catabolism of chylomicrons and VLDL. It is also required for activation of lipoprotein lipase and LCAT.


A gene on chromosome 11q23 that encodes apolipoprotein A-IV, which is a major component of high-density lipoprotein (HDL) and chylomicrons. It plays a role in chylomicrons and VLDL secretion and catabolism, and is required for efficient activation of lipoprotein lipase by ApoC-II. It is a potent activator of lecithin-cholesterol acyltransferase (LCAT).
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Apolipoprotein A-IV (apoA-IV) is an important component of "good" HDL cholesterol.
A protein in blood plasma called apolipoprotein A-IV (ApoA-IV) has been shown to keep platelets in blood plasma from clumping together.
Apolipoprotein A-IV, known as ApoA-IV, is a plasma protein.
The eight differentially expressed proteins included third party data (TPA): vitamin D-binding protein precursor (GC), complement C4 precursor (C4), paraoxonase 1 (PONI), A2M, endopin 1 (EN1), TPA: apolipoprotein A-IV precursor (APOA4), alpha-1-antitrypsin, and haptoglobin (HP).
In our quantification analysis (Figure 3), 15 proteins (amyloid-like protein 2, APLP2; apolipoprotein A-IV, APOA4; beta-2-glycoprotein 1, APOH; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, B3GNT1; complements C4-B, C4B; complements C5, C5; complement components C7, C7; monocyte differentiation antigens CD14, CD14; clusterin, CLU; fibronectin, FN1; gelsolin, GSN; inter-alpha-trypsin inhibitor heavy chain H2, ITIH2; keratin type II cytoskeletal 1, KRT1; pigment epithelium-derived factor, SERPINF1; and vitronectin, VTN) were significantly differentially expressed either in the No DR versus Mi NPDR (AUC value > 0.7) or in the No DR versus Mo NPDR (AUC value > 0.7) comparisons.
Identified proteins with expression that decreased with As exposure (higher intensity in the control gel or absent in the As-treated gel) were RAGE, glutathione-S-transferase (GST)-omega-1, contraspin (a serine--or cysteine--proteinase inhibitor isoform), apolipoprotein A-IV, and apolipoprotein A-I.
Patrick Tso, PhD, professor in the UC Department of Pathology and Laboratory Medicine, has revealed that apolipoprotein A-IV (apoA-IV) is secreted by the small intestine in response to fat absorption.
Genes involved in fatty acid synthesis, such as acetyl-CoA-carboxylase and elongation of long-chain fatty acids were reduced only by PCB-77 in corn-oil--fed mice, whereas lipid transport/export genes such as fatty acid binding protein 2 and 4, ATP-binding cassette A1, and apolipoprotein A-IV were altered in olive-oil--fed mice in response to PCBs.
Apolipoprotein A-IV (apo A-IV) is a 46-kDa plasma protein (1) with different isoforms (2).
Human Apolipoprotein A-IV binds to apolipoprotein A-I/A-II receptor sites and promotes cholesterol efflux from adipose cells.