apolipoprotein A-IV

ap·o·lip·o·pro·tein A-IV

an apolipoprotein secreted with chylomicrons and also found in HDL. It participates in the catabolism of chylomicrons and VLDL. It is also required for activation of lipoprotein lipase and LCAT.


A gene on chromosome 11q23 that encodes apolipoprotein A-IV, which is a major component of high-density lipoprotein (HDL) and chylomicrons. It plays a role in chylomicrons and VLDL secretion and catabolism, and is required for efficient activation of lipoprotein lipase by ApoC-II. It is a potent activator of lecithin-cholesterol acyltransferase (LCAT).
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The eight differentially expressed proteins included third party data (TPA): vitamin D-binding protein precursor (GC), complement C4 precursor (C4), paraoxonase 1 (PONI), A2M, endopin 1 (EN1), TPA: apolipoprotein A-IV precursor (APOA4), alpha-1-antitrypsin, and haptoglobin (HP).
Kohan AB, Wang F, Li X, et al Apolipoprotein A-IV regulates chylomicron metabolism-mechanism and function.
Patrick Tso, PhD, professor in the UC Department of Pathology and Laboratory Medicine, has revealed that apolipoprotein A-IV (apoA-IV) is secreted by the small intestine in response to fat absorption.
Identified proteins with expression that decreased with As exposure (higher intensity in the control gel or absent in the As-treated gel) were RAGE, glutathione-S-transferase (GST)-omega-1, contraspin (a serine--or cysteine--proteinase inhibitor isoform), apolipoprotein A-IV, and apolipoprotein A-I.
The biological role of apolipoprotein A-IV on chromosome segregation needs to be further investigated.
PNAS report suggests Apolipoprotein A-IV plays important role in regulating glucose homeostasis
1]B-Glycoprotein 3-6 23 Apolipoprotein A-IV 3-6 24 Apolipoprotein C-II 2-7 25 [[beta].
Genes involved in fatty acid synthesis, such as acetyl-CoA-carboxylase and elongation of long-chain fatty acids were reduced only by PCB-77 in corn-oil--fed mice, whereas lipid transport/export genes such as fatty acid binding protein 2 and 4, ATP-binding cassette A1, and apolipoprotein A-IV were altered in olive-oil--fed mice in response to PCBs.
Apolipoprotein A-IV (apo A-IV) is a 46-kDa plasma protein (1) with different isoforms (2).
Human Apolipoprotein A-IV binds to apolipoprotein A-I/A-II receptor sites and promotes cholesterol efflux from adipose cells.
A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127.