apolipoprotein A-I

ap·o·lip·o·pro·tein A-I

an apolipoprotein found in HDL and chylomicrons. It is an activator of LCAT and a ligand for the HDL receptor. A deficiency of this apolipoprotein has been associated with low HDL levels and with Tangier disease.
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 11q23-q24 that encodes apolipoprotein A1, the main protein component of high-density lipoprotein (HDL) in plasma, which promotes cholesterol efflux from tissues to the liver for excretion and is a cofactor for lecithin cholesterolacyltransferase (LCAT), which is responsible for forming most plasma cholesteryl esters.
Molecular pathology
APOA1 mutations cause HDL deficiency (e.g., Tangier disease and systemic non-neuropathic amyloidosis).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

apolipoprotein A-I

A 28 kD single chain protein that comprises 75% of the ApoA in HDL; apoA-I is the major protein constituent of lipoproteins, and participates in cholesterol transport by activating LCAT-lecithin:cholesterol acyltransferase; apoA-I levels are inversely proportional to the risk of CAD
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
According to the company, CSL112 is a novel apolipoprotein A-I infusion therapy that has been shown to have an immediate and significant impact on the ability to remove cholesterol from arteries.
The search terms used were "apolipoprotein A-I," "ApoA-I," "apolipoprotein" combining with "tumor," "neoplasms," "malignancy," "carcinoma" OR "cancer." The search language was limited to English and Chinese.
Tetranectin and apolipoprotein A-I in cerebrospinal fluid as potential biomarkers for Parkinson's disease.
Apolipoprotein A-I mimetics and high-density lipoprotein function.
Interestingly, apolipoprotein A-I, the structural protein of HDLs, was not identified as one of the proteins associated with HDL cholesterol.
Apolipoprotein B (apoB) represents the total number of apoB-containing lipoproteins [7] and is considered to be superior to LDL-C and non-HDL-C in predicting cardiovascular disease [8], whereas apolipoprotein A-I (apoA-I) has a known inverse association and low levels are associated with increased body mass index (BMI) [9].
The overwhelming majority of HDL contains apolipoprotein A-I (Apo A-I).
Jungner, "Apolipoprotein B and apolipoprotein A-I: risk indicators of coronary heart disease and targets for lipid-modifying therapy," Journal of Internal Medicine, vol.
Additionally, TB increased apolipoprotein A-I concentrations and decreased apolipoprotein B concentrations.
Secondary measures included VLDL cholesterol, apolipoprotein A-I, and apolipoprotein B.