apolipoprotein


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apolipoprotein

 [ap″o-lip″o-pro´tēn]
a nonlipid protein portion occurring in plasma lipoproteins; there are five families of apolipoproteins, grouped into four classes according to function, A, B, C, and E (the former apolipoprotein D has now been placed in class A). Apolipoproteins play a role in the transport of lipoproteins.

ap·o·lip·o·pro·tein (apo),

(ap'ō-lip'ō-prō'tēn),
The protein component of any lipoprotein complexes that is a normal constituent of plasma chylomicrons, HDL, LDL, and VLDL in humans.

apolipoprotein

(ăp′ə-lĭp′ō-prō′tēn′, -tē-ĭn, -lī′pō-)
n.
Any of various proteins that bind to insoluble lipids to form the soluble lipoproteins, such as HDL and LDL, that transport triglycerides and cholesterol within the body.

apolipoprotein

Any of a family of small proteins on the surface of lipoprotein complexes, which bind to specific enzymes or transport proteins across cell membranes, which correspond to the protein moiety of lipoproteins. See HDL-cholesterol, Kringle domain.

ap·o·lip·o·pro·tein

(ap'ō-lip-ō-prō'tēn)
The protein component of lipoprotein complexes that is a normal constituent of plasma chylomicrons, high-density lipoproteins, low-density lipoproteins, and very-low-density lipoproteins in humans.

apolipoprotein

One of a number of glycoproteins forming part of the surface of LIPOPROTEIN particles in the blood. Apolipoproteins are polar structures which provide structural stability to the lipoprotein and act as receptors that help to determine the fate of the particle. Some act as cofactors for enzymes involved in lipid and lipoprotein metabolism. The level of apolipoprotein-A is genetically induced and a high level is a strong risk factor for premature coronary heart disease. It is a feature of FAMILIAL HYPERCHOLESTEROLAEMIA. Apolipoprotein-B is the binding site of low-density lipoproteins (LDL) to cellular LDL receptors and is concerned in the movement of CHYLOMICRONS from the intestine. Apolipoprotein-C is present on chylomicrons, high-density lipoproteins and very low-density lipoproteins. Apolipoprotein-E genotyping has been used to predict the likelihood of ALZHEIMER'S DISEASE.
References in periodicals archive ?
Apolipoprotein AIV gene variant S347 is associated with increased risk of coronary heart disease and lower plasma apolipoprotein AIV levels.
[1] Nonstandard abbreviations: LC-MS, liquid chromatography-mass spectrometry; apo, apolipoprotein; CLSI, Clinical and Laboratory Standards Institute; SID-MRM, stable isotope dilution and multiple reaction monitoring; QC, quality control.
Zhou, "Preoperative apolipoprotein B/apolipoprotein A1 ratio: a novel prognostic factor for gastric cancer," OncoTargets and Therapy, vol.
Zhu, "The role of apolipoprotein E in Guillain-Barre syndrome and experimental autoimmune neuritis," Journal of Biomedicine and Biotechnology, vol.
A case--control study on the effect of Apolipoprotein E genotypes on gastric cancer risk and progression.
Apolipoprotein D expression in substantia nigra of Parkinson disease.
Your doctor also may order a test for apolipoprotein Al (apo Al), the chief protein in high-density lipoprotein (HDL, "good") cholesterol, and then calculate the ratio of apo B to apo Al.
Diagnosis and treatment of apolipoprotein B dyslipoproteinemias.
Apolipoprotein E is localised to the cytoplasm of human cortical neurons.
Bell et al., "Plasma very low density lipoproteins contain a single molecule of apolipoprotein B," Journal of Lipid Research, vol.
The complete cDNA and amino acid sequence of human apolipoprotein B-100.
Tree nut consumption--almonds, Brazil nuts, cashews, hazelnuts, macadamias, pecans, pine nuts, pistachios, and walnuts--was found to lower total cholesterol, LDL ("bad") cholesterol, apolipoprotein (ApoB), and triglycerides, said lead author Liana Del Gobbo, PhD, a researcher in cardiovascular medicine at Stanford University who conducted the study as a research fellow at Tufts' Friedman School.