Lesions were classified as fibrocystic change with or without epithelial hyperplasia if the lesion had apocrine metaplasia
, nodular adenosis, sclerosing adenosis, papillomatosis, and usual ductal hyperplasia.
Apocrine carcinomas also known as apocrine metaplasia
or sweat gland carcinoma are very rare variant of invasive breast malignancies with an incidence less than 1%.
Complex fibroadenoma refers to fibroadenomas with foci of cysts, sclerosing adenosis, epithelial calcifications, and papillary apocrine metaplasia
, and has a higher future risk of malignancy.
A striking aspect of c-erbB2 staining was that 7 of the 10 IDH lesions containing apocrine metaplasia
or hyperplasia showed focal, weak staining.
The epithelium is often of columnar morphology and/or displays usual ductal hyperplasia (UDH) and/or apocrine metaplasia
1] Several changes occur within epithelial element of fibroadenoma, including apocrine metaplasia
and varying degrees of epithelial hyperplasia, Apocrine metaplasia
is a fairly frequent component of fibroadenoma; however, fibroadenoma with squamous metaplasia is a rare entity.
Papillary apocrine metaplasia
is a common papillary lesion that is associated with breast cysts.
Normal Apocrine Cells, Apocrine Metaplasia
, and Apocrine Adenosis
Epitheliosis, apocrine metaplasia
, pseudo angiomatous stromal hyperplasia, atrophy and cystically dilated ducts were among the major microscopic features observed.
Juvenile papillomatosis is characterized by the presence of multiple dilated ducts and cysts, extensive UDH, extensive apocrine metaplasia
, apocrine papillary hyperplasia, and intraductal and intracystic papillomas (Figure 1, a and b).
1 Similarly fibroadenoma with apocrine metaplasia
and multinucleated stromal giant cells occur rarely in the age group found in our series.
Focal apocrine metaplasia
is frequently seen within intraductal papillomas but is almost always absent in intraductal papillary carcinomas, making it a useful adjunct in the differential diagnosis along with other features (Figure 3, A and B).