apocrine carcinoma


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Related to apocrine carcinoma: sebaceous carcinoma, apocrine adenoma

ap·o·crine car·ci·no·ma

1. a carcinoma composed predominantly of cells with abundant eosinophilic granular cytoplasm, occurring in the breast or other sites;
2. a carcinoma of the apocrine glands.

apocrine carcinoma

An uncommon type of breast carcinoma (±4% of all breast cancers) for which 90+% of the malignant cells are defined as apocrine, either by immunohistochemistry (GCDFP-15, androgen receptor +ve) or cytologically (eosinophilic cells with prominent nucleoli).

ap·o·crine car·ci·no·ma

(ap'ō-krin kahr'si-nō'mă)
1. A carcinoma composed predominantly of secretory cells with abundant eosinophilic granular cytoplasm, occurring in the breast.
2. A carcinoma of the apocrine glands, especially those found in the groin and axilla.
References in periodicals archive ?
Apocrine carcinomas also known as apocrine metaplasia or sweat gland carcinoma are very rare variant of invasive breast malignancies with an incidence less than 1%.
Molecular pathology of breast apocrine carcinomas: a protein expression signature specific for benign apocrine metaplasia.
Clear cell invasive apocrine carcinomas of the breast show nests and sheets polygonal cells with abundant foamy cytoplasm round to oval vesicular nuclei and prominent nucleoli.
(10-12) About 25% to 75% of TNBCs show androgen receptor (AR) expression; many, but not all, of these tumors are apocrine carcinomas. (13-17) It is this latter group ([AR.sup.+] TNBCs) that is of special interest in this review for a potential benefit from AR-targeted therapies.
Androgen and estrogen receptor mRNA status in apocrine carcinomas. Diagn Mol Pathol.
Apocrine Carcinoma.--Cutaneous apocrine carcinomas are rare, and only rare cases of vulvar apocrine carcinoma have been reported in the literature.
Apocrine carcinoma. Cribriform architecture and polygonal neoplastic cells with eosinophilic cytoplasm are characteristic features of apocrine carcinoma (hematoxylin-eosin, original magnification X200).
Lipid or glycogen-rich carcinoma, mucinous carcinoma, acinic cell carcinoma, apocrine carcinoma, and cystic hypersecretory carcinoma are primary malignant lesions that may resemble secretory carcinoma morphologically.
Apocrine carcinomas are invasive ductal carcinomas in which all or nearly all of the tumor cells have apocrine cytologic features, including prominent eosinophilic, flocculent cytoplasm with sharply defined cell borders, and large nuclei containing prominent macronucleoli.
Of the 26 cases with known negative lymph nodes, 16 (62%) were invasive ductal carcinomas, 8 (31%) were medullary/atypical medullary carcinomas, 1 was an invasive lobular carcinoma, and 1 was an apocrine carcinoma (Table 2).
Apocrine carcinomas are special types of breast tumors which are composed of dark eosinophilic, granular, and vacuolated cytoplasms and significant nuclei.