References in periodicals archive ?
Akcea's drug pipeline includes novel antisense drugs designed to address a number of lipid risk factors, including LDL-Cholesterol, apoC-III, triglycerides and Lp(a).
The gene in question codes for the apoC-III protein.
This finding, if confirmed in ongoing studies, could lead to better evaluation of risk of heart disease in individuals and to more precise targeting of treatments to raise the protective HDL or lower the unfavourable HDL with apoC-III," said Frank Sacks, professor of cardiovascular disease prevention at HSPH and senior author of the study.
Gel bands containing apoB100, apoE, and comigrating apoC-I, apoC-II, and apoC-III were excised with an EXQuest Spot Cutter (Bio-Rad).
Foxo1 cause lipid metabolism through induction of G6Pase, apoC-III, and Igfbp-1 expression (Nakae et al.
Compounds that target the apoC-III protein or the APOC3 gene that encodes it might be useful in the fight against heart disease, said the researchers.
The gene, known as APOC3, produces a protein, apoC-III, that normally inhibits the breakdown of triglycerides.
Acikladigim biyolojik cercevede sigara icmenin gobeklilik ve sismanligi azaltici vasfinin yam sira, kanda insulin duzeylerini, apoC-III ve kompleman C3 duzeylerini azaltici gibi onemli olumlu nitelikleri bulundugunu belgeledik.
For these patients in particular, the potential benefit of inhibiting the synthesis of apoC-III is very promising.
In particular, apoC-III in VLDL subclasses that are denser and smaller are associated with CAD.
Carriers of the mutation have half the amount of apoC-III, a protein linked to triglycerides, than people without the gene variant.
ApoC-III retards the clearance of triglyceride-rich apoB-containing lipoproteins by inhibiting lipoprotein lipase (LPL), and as such plays a pivotal role in the catabolism of triglycerides (5).
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