APOC3

(redirected from apoC-III)

APOC3

A gene on chromosome 11q23.1-q23.2 that encodes apolipoprotein C-III, a very low-density lipoprotein (VLDL) protein that inhibits lipoprotein and hepatic lipases; it is thought to delay catabolism of triglyceride-rich particles.
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In this first-in-human study, AKCEA-APOCIII-LRx achieved substantial sustained reductions of apoC-III and triglyceride levels.
Volanesorsen, developed using Ionis' proprietary antisense technology, is designed to reduce the production of ApoC-III, a protein that is produced in the liver and plays a central role in the regulation of plasma triglycerides.
Impaired renal function contributes to the above-mentioned, because the kidneys are involved in the elimination of apoC-III from the plasma.
The gene in question codes for the apoC-III protein.
This finding, if confirmed in ongoing studies, could lead to better evaluation of risk of heart disease in individuals and to more precise targeting of treatments to raise the protective HDL or lower the unfavourable HDL with apoC-III," said Frank Sacks, professor of cardiovascular disease prevention at HSPH and senior author of the study.
Gel bands containing apoB100, apoE, and comigrating apoC-I, apoC-II, and apoC-III were excised with an EXQuest Spot Cutter (Bio-Rad).
Acikladigim biyolojik cercevede sigara icmenin gobeklilik ve sismanligi azaltici vasfinin yam sira, kanda insulin duzeylerini, apoC-III ve kompleman C3 duzeylerini azaltici gibi onemli olumlu nitelikleri bulundugunu belgeledik.
The gene, known as APOC3, produces a protein, apoC-III, that normally inhibits the breakdown of triglycerides.
Compounds that target the apoC-III protein or the APOC3 gene that encodes it might be useful in the fight against heart disease, said the researchers.
Foxo1 cause lipid metabolism through induction of G6Pase, apoC-III, and Igfbp-1 expression (Nakae et al.
ApoC-III is a protein produced in the liver that plays a central role in the regulation of serum triglycerides.