APOC3

(redirected from apoC-III)

APOC3

A gene on chromosome 11q23.1-q23.2 that encodes apolipoprotein C-III, a very low-density lipoprotein (VLDL) protein that inhibits lipoprotein and hepatic lipases; it is thought to delay catabolism of triglyceride-rich particles.
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WAYLIVRA is designed to reduce the production of apolipoprotein C-III (apoC-III), a protein produced in the liver that plays a central role in the regulation of plasma triglycerides.
(NASDAQ: ARWR) has dosed the first subjects in a Phase 1 clinical study of ARO-APOC3, an RNAi-based investigational medicine targeting Apolipoprotein C-III (apoC-III) being developed for the treatment of hypertriglyceridemia, the company said.
Apoc-III antisense oligonucleotides: a new option for the treatment of hypertriglyceridemia.
Volanesorsen, developed using Ionis' proprietary antisense technology, is designed to reduce the production of ApoC-III, a protein that is produced in the liver and plays a central role in the regulation of plasma triglycerides.
Results showed a 66% drop in triglycerides, 68% in apoliprotein C-III (ApoC-III), 35% in LDL cholesterol, and 36% in total cholesterol.
Apolipoprotein C-III (apoC-III) is secreted with VLDL and becomes distributed among circulating lipoproteins [11] conferring harmful properties resulting in ACVD [3, 12].
The regulatory role of apoE and apoC-III lipoproteins in the apoB metabolism was studied in a recent work on healthy subjects and patients with hypertriglyceridemia [50].
It was recently shown that apolipoprotein C-III (apoC-III), which is highly correlative to plasma TG levels, inhibits the hepatic clearance of TRLs by both LRP1 and LDLR [39].
It is primarily due to increase in plasma ApoC-III levels.8 There is also down regulation of lipoprotein lipase, hepatic lipase and the VLDL receptor and upregulation of hepatic acyl-CoA cholesterol acyltransferase (ACAT).2
The gene in question codes for the apoC-III protein.
For example, in my lab we're looking at ApoC-III, a small inflammatory protein on the surface of some HDL particles.