References in periodicals archive ?
WAYLIVRA is designed to reduce the production of apolipoprotein C-III (apoC-III), a protein produced in the liver that plays a central role in the regulation of plasma triglycerides.
(NASDAQ: ARWR) has dosed the first subjects in a Phase 1 clinical study of ARO-APOC3, an RNAi-based investigational medicine targeting Apolipoprotein C-III (apoC-III) being developed for the treatment of hypertriglyceridemia, the company said.
Apoc-III antisense oligonucleotides: a new option for the treatment of hypertriglyceridemia.
Volanesorsen, developed using Ionis' proprietary antisense technology, is designed to reduce the production of ApoC-III, a protein that is produced in the liver and plays a central role in the regulation of plasma triglycerides.
Results showed a 66% drop in triglycerides, 68% in apoliprotein C-III (ApoC-III), 35% in LDL cholesterol, and 36% in total cholesterol.
Apolipoprotein C-III (apoC-III) is secreted with VLDL and becomes distributed among circulating lipoproteins  conferring harmful properties resulting in ACVD [3, 12].
The regulatory role of apoE and apoC-III lipoproteins in the apoB metabolism was studied in a recent work on healthy subjects and patients with hypertriglyceridemia .
It was recently shown that apolipoprotein C-III (apoC-III), which is highly correlative to plasma TG levels, inhibits the hepatic clearance of TRLs by both LRP1 and LDLR .
It is primarily due to increase in plasma ApoC-III levels.8 There is also down regulation of lipoprotein lipase, hepatic lipase and the VLDL receptor and upregulation of hepatic acyl-CoA cholesterol acyltransferase (ACAT).2
The gene in question codes for the apoC-III protein.
For example, in my lab we're looking at ApoC-III, a small inflammatory protein on the surface of some HDL particles.
Medical browser ?
- apneustic center
- apneustic respiration
- apnoea-hypopnoea score
- apo A-IV
- Apocard 01
- apochromatic lens
- apochromatic objective
- apocrine carcinoma
- apocrine chromesthesia
- apocrine chromhidrosis
- apocrine gland
- apocrine glands
- apocrine metaplasia
- apocrine miliaria
- apocrine secretion
- apocrine sweat gland
- apocrine sweat glands
- APOE genotype
Full browser ?
- ApoB 100
- ApoB-apo-A-I ratio
- Apocalypse 2012
- Apocalypse Gaming
- Apocalypse Now
- Apocalypse of Esdras
- Apocalypse of John
- Apocalypse of St John
- Apocalypse of St John the Apostle
- Apocalypse of St John the Divine
- Apocalypse of St. John the Apostle
- APOCALYPSE pRODUCTION cREW
- Apocalypse, Book of