Couture, "Effect of ezetimibe on the in vivo kinetics of apoB-48 and apoB-100
in men with primary hypercholesterolemia," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
It has been suggested that the APOB rs11279109 DD genotype results in a 66% reduction in the translocation of the APOB-100
from the endoplasmic reticulum along with the increased hydrophobicity  that may result in slower transfer of the APOB-100
and formation of LDL particles.
The aim of this study was to investigate the genetic variations in coding region of exon 29 of ApoB-100
encoding gene in hypercholesterolemic families and their prevalence among CHD patients of Punjab origin.
Selective modification of apoB-100
in the oxidation of low density lipoproteins by myeloperoxidase in vitro.
The results of some tests  pointed out that the mediators of inflammation in the blood of patients with CKD increase apoC-III gene expression and that inflammation with an increased concentration of apoC-III delays VLDL apoB-100
catabolism and its subclasses .
reuteri organisms in capsule form for nine weeks, LDL cholesterol fell by nearly 12%, total cholesterol fell by 9%, non-HDL cholesterol fell by 11%, and apoB-100
fell by 8%, with a reduction in the LDL to HDL cholesterol ratio of 13%.6
Simon-Broome criteria fails to differentiate between classical FH due to LDLR mutations and the other genetic origins of FH such as ApoB-100
Com a perda de algumas apolipoproteinas e de TAG ele origina a IDL, que ainda mantem apoB-100
, apoC, apoE, em sua formacao.
In this situation, phospholipids, triacylglycerol, and cholesterol esters are transformed into hydroperoxides which react with ApoB-100
, resulting in modification and fragmentation of amino acid side chains [14, 15].
Mipomersen is a second-generation antisense drug currently in phase 3 development that reduces the production of apoB-100
, a protein critical to the synthesis and transport of "bad" cholesterol.
A VLDL e entao liberada pelo figado como particulas nascentes contendo apoB-100
como principal apolipoproteina, e da mesma forma que acontece com os quilomicrons, estas lipoproteinas sofrem a acao da enzima lipase lipoproteica, que hidrolisa os triglicerideos, originando um remanescente mais denso, a IDL.