APOB

(redirected from apoB-100)
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APOB

A gene on chromosome 2p24-p23 that encodes apolipoprotein B, the main apoliprotein of chylomicrons and low-density lipoproteins, which appears in plasma as two main isoforms: apoB48 (which is synthesised exclusively in the gut) and apoB100 (which is synthesised in the liver).

Molecular pathology
APOB mutations cause hypobetalipoproteinaemia, normotriglyceridemic hypobetalipoproteinaemia, and hypercholesterolaemia due to ligand-defective apoB.
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References in periodicals archive ?
Couture, "Effect of ezetimibe on the in vivo kinetics of apoB-48 and apoB-100 in men with primary hypercholesterolemia," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
The Interpretation of Cholesterol Balance Derived Synthesis Data and Surrogate Noncholesterol Plasma Markers for Cholesterol Synthesis under Lipid Lowering Therapies
It has been suggested that the APOB rs11279109 DD genotype results in a 66% reduction in the translocation of the APOB-100 from the endoplasmic reticulum along with the increased hydrophobicity [33] that may result in slower transfer of the APOB-100 and formation of LDL particles.
Increased Risk of the APOB rs11279109 Polymorphism for CHD among the Kuwaiti Population
The aim of this study was to investigate the genetic variations in coding region of exon 29 of ApoB-100 encoding gene in hypercholesterolemic families and their prevalence among CHD patients of Punjab origin.
A Genetic Variant (S4338N) in Apolipoprotein B Gene in Hypercholesterolemic Families from Pakistan
Selective modification of apoB-100 in the oxidation of low density lipoproteins by myeloperoxidase in vitro.
Study of oxidative and inflammatory parameters in LDLr-KO mice treated with a hypercholesterolemic diet: comparison between the use of Campomanesia xanthocarpa and acetylsalicylic acid
The results of some tests [64] pointed out that the mediators of inflammation in the blood of patients with CKD increase apoC-III gene expression and that inflammation with an increased concentration of apoC-III delays VLDL apoB-100 catabolism and its subclasses [63].
Role of Myeloperoxidase in Patients with Chronic Kidney Disease
reuteri organisms in capsule form for nine weeks, LDL cholesterol fell by nearly 12%, total cholesterol fell by 9%, non-HDL cholesterol fell by 11%, and apoB-100 fell by 8%, with a reduction in the LDL to HDL cholesterol ratio of 13%.6
Unique probiotic targets cardiovascular disease
Simon-Broome criteria fails to differentiate between classical FH due to LDLR mutations and the other genetic origins of FH such as ApoB-100 and PCSK9.
Criteria for diagnosis of familial hypercholesterolemia: a comprehensive analysis of the different guidelines, appraising their suitability in the Omani Arab population
Com a perda de algumas apolipoproteinas e de TAG ele origina a IDL, que ainda mantem apoB-100, apoC, apoE, em sua formacao.
Brief description of diabetes mellitus type II and the relation with lipids metabolism, resistance training and its effects: breaking rules/Breve relato da diabete tipo II e sua relacao com o metabolismo de lipideos, o exercicio resistido e os efeitos deste: quebrando dogmas
In this situation, phospholipids, triacylglycerol, and cholesterol esters are transformed into hydroperoxides which react with ApoB-100, resulting in modification and fragmentation of amino acid side chains [14, 15].
Oxidized LDL induces alternative macrophage phenotype through activation of CD36 and PAFR
Mipomersen is a second-generation antisense drug currently in phase 3 development that reduces the production of apoB-100, a protein critical to the synthesis and transport of "bad" cholesterol.
Genzyme and Isis Obtain Apolipoprotein B (apoB) Expression Antisense Modulation Patent
A VLDL e entao liberada pelo figado como particulas nascentes contendo apoB-100 como principal apolipoproteina, e da mesma forma que acontece com os quilomicrons, estas lipoproteinas sofrem a acao da enzima lipase lipoproteica, que hidrolisa os triglicerideos, originando um remanescente mais denso, a IDL.
Analysis of the alterations of weight and dyslipidemias in workers of siderurgical submitted to one program of changes in weight multidisciplinary/Analise das alteracoes de peso e dislipidemia em trabalhadores de siderurgica submetidos a um programa de emagrecimento multidisciplinar

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