APOB

(redirected from apoB-100)
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APOB

A gene on chromosome 2p24-p23 that encodes apolipoprotein B, the main apoliprotein of chylomicrons and low-density lipoproteins, which appears in plasma as two main isoforms: apoB48 (which is synthesised exclusively in the gut) and apoB100 (which is synthesised in the liver).

Molecular pathology
APOB mutations cause hypobetalipoproteinaemia, normotriglyceridemic hypobetalipoproteinaemia, and hypercholesterolaemia due to ligand-defective apoB.
References in periodicals archive ?
Couture, "Effect of ezetimibe on the in vivo kinetics of apoB-48 and apoB-100 in men with primary hypercholesterolemia," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
It has been suggested that the APOB rs11279109 DD genotype results in a 66% reduction in the translocation of the APOB-100 from the endoplasmic reticulum along with the increased hydrophobicity [33] that may result in slower transfer of the APOB-100 and formation of LDL particles.
The aim of this study was to investigate the genetic variations in coding region of exon 29 of ApoB-100 encoding gene in hypercholesterolemic families and their prevalence among CHD patients of Punjab origin.
The results of some tests [64] pointed out that the mediators of inflammation in the blood of patients with CKD increase apoC-III gene expression and that inflammation with an increased concentration of apoC-III delays VLDL apoB-100 catabolism and its subclasses [63].
reuteri organisms in capsule form for nine weeks, LDL cholesterol fell by nearly 12%, total cholesterol fell by 9%, non-HDL cholesterol fell by 11%, and apoB-100 fell by 8%, with a reduction in the LDL to HDL cholesterol ratio of 13%.6
Simon-Broome criteria fails to differentiate between classical FH due to LDLR mutations and the other genetic origins of FH such as ApoB-100 and PCSK9.
In this situation, phospholipids, triacylglycerol, and cholesterol esters are transformed into hydroperoxides which react with ApoB-100, resulting in modification and fragmentation of amino acid side chains [14, 15].
Mipomersen is a second-generation antisense drug currently in phase 3 development that reduces the production of apoB-100, a protein critical to the synthesis and transport of "bad" cholesterol.
A VLDL e entao liberada pelo figado como particulas nascentes contendo apoB-100 como principal apolipoproteina, e da mesma forma que acontece com os quilomicrons, estas lipoproteinas sofrem a acao da enzima lipase lipoproteica, que hidrolisa os triglicerideos, originando um remanescente mais denso, a IDL.