APOB

(redirected from apoB-100)
Also found in: Encyclopedia.

APOB

A gene on chromosome 2p24-p23 that encodes apolipoprotein B, the main apoliprotein of chylomicrons and low-density lipoproteins, which appears in plasma as two main isoforms: apoB48 (which is synthesised exclusively in the gut) and apoB100 (which is synthesised in the liver).

Molecular pathology
APOB mutations cause hypobetalipoproteinaemia, normotriglyceridemic hypobetalipoproteinaemia, and hypercholesterolaemia due to ligand-defective apoB.
Mentioned in ?
References in periodicals archive ?
The aim of this study was to investigate the genetic variations in coding region of exon 29 of ApoB-100 encoding gene in hypercholesterolemic families and their prevalence among CHD patients of Punjab origin.
A Genetic Variant (S4338N) in Apolipoprotein B Gene in Hypercholesterolemic Families from Pakistan
Selective modification of apoB-100 in the oxidation of low density lipoproteins by myeloperoxidase in vitro.
Study of oxidative and inflammatory parameters in LDLr-KO mice treated with a hypercholesterolemic diet: comparison between the use of Campomanesia xanthocarpa and acetylsalicylic acid
The results of some tests [64] pointed out that the mediators of inflammation in the blood of patients with CKD increase apoC-III gene expression and that inflammation with an increased concentration of apoC-III delays VLDL apoB-100 catabolism and its subclasses [63].
Role of Myeloperoxidase in Patients with Chronic Kidney Disease
Simon-Broome criteria fails to differentiate between classical FH due to LDLR mutations and the other genetic origins of FH such as ApoB-100 and PCSK9.
Criteria for diagnosis of familial hypercholesterolemia: a comprehensive analysis of the different guidelines, appraising their suitability in the Omani Arab population
Mipomersen is a second-generation antisense drug that reduces the production of apoB-100, a protein critical to the synthesis and transport of "bad" cholesterol.
FDA PROVIDES CLARITY TO ISIS ON MIPOMERSEN REQUIREMENTS
Estimation of the age of the ancestral arginine3500 [right arrow] glutamine mutation in human apoB-100.
Absence of apolipoprotein B-3500 mutation in Turkish patients with coronary and cerebrovascular atherosclerosis/Koroner ve serebrovaskuler aterosklerozlu Turk hastalarda apolipoprotein B-3500 mutasyonu yoklugu
The therapy is intended to reduce the production of ApoB-100, a protein that carries certain forms of cholesterol and triglycerides in the blood.
Cleveland Clinic announces the "Top 10 Medical Innovations" for 2008
Additionally, a large apoB-100 molecule is located at one pole of the LDL and acts as a recognition site for LDL receptors on almost all cells of the body (Pentikainen et al.
Update on risk factors for atherosclerosis: the role of inflammation and apolipoprotein E
There was also no change in the plasma lathosterol, serum apoB-100 or lipids with chronic black tea ingestion.
Effect of black tea on the fasting concentrations of chylomicrons and chylomicron remnants in humans. (Original Research)
Hypercholesterolemia increases myocardial oxidative and nitrosative stress thereby leading to cardiac dysfunction in apoB-100 transgenic mice.
Association between oxidative stress index and serum lipid levels in healthy young adults
La apoB-100 es la principal apolipoproteina encontrada en el colesterol LDL, otras son las lipoproteinas de densidad intermedia (IDL), las lipoproteinas de muy baja densidad (VLDL) y la lipoproteina a, Lp(a).
Ronda clinica y epidemiologica
We conclude that a redox active copper-rutin-complex is still able to initiate the LDL oxidation but may prevent copper from a reaction at the binding sites of apoB-100.
Synergistic inhibition of low-density lipoprotein oxidation by rutin, [gamma]-terpinene, and ascorbic acid

Medical browser ?
Full browser ?