APOA2

(redirected from apoAII)

APOA2

A gene on chromosome 1q21-q23 that encodes apolipoprotein A2, a protein component of high-density lipoprotein (HDL), which is present in plasma as a monomer, homodimer or heterodimer with apolipoprotein D.

Molecular pathology
APOA2 mutations cause apolipoprotein A2 deficiency or hypercholesterolaemia.
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References in periodicals archive ?
HDL containing apoA-I and apoAII helps to degrade cholesterol from VLDL and chylomicron by reverse cholesterol transport from peripheral tissue to liver [8].
The remainder is chiefly apoAi and apolipoprotein Aii (apoAii).
Yu et al., "Expression of human ApoAII in transgenic rabbits leads to dyslipidemia: a new model for combined hyperlipidemia," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
Differential tissue-specific expression of human apoA-I and apoAII. J Lipid Res 1991;32:821-8.
Lipids and lipoproteins metabolism in humans may be controlled by genes, including the lipoprotein lipase, apo AI, apo E, apo B, apo C, apoAII, and lecithin: cholesterol acyltransferase genes, because of their central position in the lipids metabolism regulationt (19,20).
They include apoAI, apoAII, apoAIV, apoAV, apoCI, apoCII, apoCIII and apoE as well as several lesser-known apoproteins.
The annealing temperature was lowered to 58 [degrees]C for ApoD and ApoAII genes and 55 [degrees]C for UCP3, UCP2, IRS-1, Ob-Rb, HSL, RxR, and LPL.
Compared to native LDL, it has an increased content of several non-apoB apolipoproteins: apoE, apoCIII, apoAI, apoAII, apoD, apoF, and apoJ [25].
Micronized fenofibrate is a fibric acid derivative that reduces serum TC, LDL-C, TG, and VLDL-cholesterol and increases the concentrations of HDL-C, apoAI, and apoAII (22).
[3] Nonstandard abbreviations: IMT, intima-media thickness; TC, total cholesterol; LDL-C, LDL-cholesterol; TG, triglyceride; HDL-C, HDL-cholesterol; hsCRP, high-sensitivity C-reactive protein; apoB100, apolipoprotein B100; apoAI, apolipoprotein AI; IL-1, interleukin-1; IL-6, interleukin-6; IFN-[gamma], interferon [gamma]; TNF-[alpha], tumor necrosis factor; OxLDL, oxidized LDL; NO, nitric oxide; apoAII, apolipoprotein II; D, diameter; CCAIMT, common carotid artery IMT; ICAIMT, internal carotid artery IMT.
In addition to apoE, the CSF also contains apoAI, apoAII, apoAVI, apoD, and apoJ (8-10) but not apoB (the only apolipoprotein included in the LDL fraction, and the major lipoprotein in plasma involved in cholesterol transport).
Purified apos (apoAI, apoAII, apoB, apoCII, apoCIII, and apoE), anti-apoE polyclonal antibody (rabbit), anti-apoE monoclonal antibody, and horseradish peroxidase-conjugated anti-mouse IgG (goat) were purchased from Chemicon International Inc., Dako, Progen Biotechnik, and MBL Co., respectively.