APOC3

(redirected from apo-CIII)

APOC3

A gene on chromosome 11q23.1-q23.2 that encodes apolipoprotein C-III, a very low-density lipoprotein (VLDL) protein that inhibits lipoprotein and hepatic lipases; it is thought to delay catabolism of triglyceride-rich particles.
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(in "Apolipoprotein CIII Overexpression Induced Hypertriglyceridemia Increases Nonalcoholic Fatty Liver Disease in Association with Inflammation and Cell Death") demonstrated that persistent hypertriglyceridemia might be more relevant to liver inflammation than intracellular lipid accumulation and that overexpression of apo-CIII increases severity of diet-induced fatty liver disease.
We studied apo-CIII, which is known to correlate with triglycerides and triglyceride-rich lipoproteins and plays an important role in modulating their lipolytic degradation (12) and in preventing their uptake by the LDL receptor (13).