APOA1

(redirected from apo-AI)

APOA1

A gene on chromosome 11q23-q24 that encodes apolipoprotein A1, the main protein component of high-density lipoprotein (HDL) in plasma, which promotes cholesterol efflux from tissues to the liver for excretion and is a cofactor for lecithin cholesterolacyltransferase (LCAT), which is responsible for forming most plasma cholesteryl esters.
 
Molecular pathology
APOA1 mutations cause HDL deficiency (e.g., Tangier disease and systemic non-neuropathic amyloidosis).
References in periodicals archive ?
He holds many awards and honours in both Denmark and the USA and his research has concentrated on genetic variations related to cardiovascular disease, and, most recently, on composition and function of HDL in patients with ischemic heart disease, and on apo-AI mimetic peptides in animal models of atherosclerosis.
Later, as an NIH postdoc, he focused on such topics as the compositional and functional properties of HDL in patients with ischemic heart disease, and the characterization and function of new Apo-AI mimetic peptides potentially to be used as HDL-C raising compounds.