aplastic anaemia


Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to aplastic anaemia: megaloblastic anaemia

aplastic anaemia

Anaemia due to a failure in marrow production of RBCs, often accompanied by failure in WBC and platelet production (i.e., granulocytopaenia, thrombocytopaenia).
 
Aetiology
Toxins (benzene, toluene, insecticides), radiotherapy, drugs (carbamazepine, chemotherapy, chloramphenicol, gold salts, phenytoin, phenylbutazone, quinacrine, sulfonamides, tolbutamide), autoimmunity, SLE, post-hepatitis, pregnancy, paroxysmal nocturnal haemoglobinuria.

Prognosis
Aplastic anaemia is often unresponsive to specific therapy.

aplastic anaemia

A serious form of anaemia in which no new blood cells are formed in the bone marrow. About 30% of cases follow virus infections, especially MEASLES, MUMPS and HEPATITIS or are induced by drugs such as BUTAZOLIDINE, SULPHONAMIDES, CHLORAMPHENICOL or dipyrone. The condition results from damage to the haemopoietic stem cells often from an autoimmune process that can be checked by immunosuppressive drug treatment. Blood transfusions are often necessary to maintain life.
References in periodicals archive ?
So when Paddy was diagnosed with aplastic anaemia, we were left shell-shocked again.
A study by Kumar et al on 166 cases of pancytopenia showed that four main causes were aplastic anaemia (49 cases), megaloblastic anaemia (37 cases), aleukaemic leukaemia/lymphoma (30 cases) and hypersplenism (19 cases).
Gordon-Smith, "Haemopoietic growth factor production by normal and aplastic anaemia stroma in long-term bone marrow culture," British Journal of Haematology, vol.
A small number of patients with aplastic anaemia may develop leukaemia.
Causes of haematological thrombocytopenia studied included acute lymphoblastic leukaemia (ALL), aplastic anaemia (AP), and ITP.
(5.) Scheinberg P, Nunez 0, Wu C, Young NS: Treatment of severe aplastic anaemia with combined immunosuppression: anti-thymocyte globulin, cyclosporin and mycophenolate mofetil.
Aplastic Anaemia sufferer Emily has recently received new donor blood cells, but has a severely weakened immune system and is being kept in isolation to reduce the chances of becoming infected.
When Liam was struck down by aplastic anaemia, a serious, rare disease caused by the bone marrow failing to produce blood cells, mum Claire, 35, had never even heard of the condition.
Anthony Leedham, from Harton in South Shields, was due to celebrate his 20th birthday in a few days, but died on Friday as a result of aplastic anaemia - a condition that affects just one in 500,000 people each year.
The Huyton youngster suffered from aplastic anaemia - a condition which stops the production of blood cells.
Faye, who is a pupil at St Anne's RC primary school, has aplastic anaemia which stops production of blood cells.
Two-year-old Billy suffers from Severe Aplastic Anaemia and is in need of a bone marrow and stem cell transplant.