In 2010, in an effort to improve clinical sensitivity in diagnosing BD, revised diagnostic criteria were proposed by the international criteria for BD. These criteria included oral aphthosis
, genital ulcers, ocular manifestations, skin lesions, vascular manifestations of different sizes in various organs, central nervous system involvement, and positive pathergy test.
in discoid lupus erythematosus, PN, Behcet's disease, oral aphthosis
, pyoderma gangrenosum, actinic prurigo, Jessner's lymphocytic infiltrate, sarcoidosis, and recurrent erythema multiforme.
Oral manifestations that interest gums such as aphthous ulcers or recurrent aphthosis
are correlated to celiac disease-affected patients.
There was no familial history of autoimmune diseases, but her father had some episodes of oral aphthosis
. Immunological examination was positive for rheumatoid factor (RF--22.3 UI; normal: <15 UI), anti-nuclear antibodies [ANA (speckled, titer 1:320)] and antibodies to SSA/Ro (SSA 3+/ Ro52KD 3+)--initial screening step of ANA by indirect immunofluorescence on HEp-2 cells (Euroimmun[R], Germany); autoantibodies confirmation assay by line immunoblot (ANA profile 3 Euroimmun[R], Germany)--antibodies detected on strips were evaluated semiquantitatively (negative, 1+, 2++, and 3+++).
The ICBD criteria included recurrent oral and genital aphthosis
, eye lesions (anterior or posterior uveitis, cells in vitreous on slit lamp examination, and retinal vasculitis), skin lesions (erythema nodosum, pseudofollicolitis or papulopustular lesions, and acneiform nodules), neurological manifestation, vascular manifestation, and/or a positive pathergy test .
During the first visit in our center, the patient, who was still receiving CsA 5 mg/kg/day and prednisone 25 mg/day, presented severe uveitis and retinal vasculitis of the left eye with reduced best-corrected visual acuity (VA) (Snellen chart of 0.1-1.0 at a distance of 5 meters: 0.2), oral aphthosis
, and left knee and left wrist arthritis.
is the most common clinical feature and is usually the first manifestation .
It is associated with a delayed wound healing, oral aphthosis
, edema, pulmonary toxicity, bacterial infections, thrombocytopenia, hyperlipidemia, and proteinuria .
A 12-year-old female patient, with history of recurrent oral aphthosis
, was originally admitted at our university hospital in September 2014 for progressively increasing pancranial headache, stiff neck, left oculomotor paresis, left facial nerve paresis, unstable gait, and left hemiparesis.
Haematological deficiencies in patients with recurrent aphthosis
. J Eur Acad Dermatol Venereol 2010;24(6): 667-73.
The therapeutic effect of cigarette smoking on oral/genital aphthosis
and other manifestations of Behcet's disease.
The triad of recurrent oral aphthosis
, genital ulcer, and uveitis are the main classic presentations of the BD.