Cardiology genomic testing helps in detecting diseases such as aortopathy
and congenital heart diseases.
Therefore, our data that demonstrate a decrease in adiponectin level and elevation of inflammatory and oxidative stress biomarkers and aortopathy
are in agreement with these studies.
Chances of risk of aortic rupture or dissection increases during pregnancy, secondary to changes in aortic wall, aortopathy
and long-standing hypertension.
Kim et al., "Echocardiographic evidence of innate aortopathy
in the human intracranial aneurysm," PLoS ONE, vol.
Fu et al., "Genetic testing of 248 Chinese aortopathy
patients using a panel assay," Scientific Reports, vol.
Ravi et al., "The aortic stenosis complex: aortic valve, atherosclerosis, aortopathy
," Journal of Cardiology, vol.
Bicuspid aortic valves due to accelerated degeneration predispose to aortic aortopathy
manifesting as aortic valvular stenosis (36), ascending aorta and aortic root dilatation out of proportion to hemodynamic factors, and true SOV aneurysms (37-39).
Many theories have been postulated about the cause of aortopathy
Radiation-induced tissue damage also accelerates arteriosclerosis and aortopathy
. Peripheral fibrosis, calcification, thrombosis, and severe stenosis or even occlusion of small blood vessels including the vasa vasorum induce fragility of large vessels, eventually resulting in perforation of the aorta [3, 8-12].
This associated aortopathy
has been thought to be caused by increased activity of intrinsic tissue structures such as matrix metalloproteinases and protein kinases within the intima and adventitia of the vessel, during embryogenesis, which predisposes these patients to aneurysms.
Intrinsic histological abnormalities of aortic root and ascending aorta in tetralogy of Fallot: evidence of causative mechanism for aortic dilatation and aortopathy
. Circulation 112, 961-968.
In this study, all of the aortopathy
groups had an increase in Mn- and Cu-Zn-SOD, which correlated with increased LPO with the exception of TA.