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To simulate the prehypertensive SS baroreceptor systemic phenotype of partial baroreceptor impairment (10,13), a chronic bilateral aortic denervation was performed instead of a chronic bilateral carotid sinus denervation, because the destruction of chemoreceptors during the carotid sinus denervation (22,23) in a species like the rat, which lacks functional aortic body chemoreceptors (25), causes chronic hypoventilation with consequent chronic systemic hypoxia, which in turn has the chronic effect of lowering blood pressure (23).
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