Some preliminary studies have evaluated the antiurolithic potential of B.
Gilani, "Antiurolithic effect of Bergenia ligulata rhizome: an explanation of the underlying mechanisms," Journal ofEthnopharmacology, vol.
Khobragade, "Exploring glycolate oxidase (GOX) as an antiurolithic drug target: Molecular Modeling and In Vitro Inhibitor Study," International Journal of Biological Macromolecules, vol.
Such medicines are considered safe and present minimal or no side effects, and studies [7-9] have indicated that numerous herbs, including Viburnum opulus L., Desmodium styracifolium, and Solanum xanthocarpum, can be useful antiurolithic agents due to their antioxidant properties.
To investigate the medicinal applicability of Glechoma longituba in urolithiasis, we evaluated an extract for its antiurolithic activity using an in vitro assay and an in vivo rat model of urolithiasis.
KCit has been proven to be useful for controlling calcareous stones by increasing urinary citrate; thus, in the present study, KCit appears to have produced an antiurolithic effect mainly by increasing urinary citrate rather than by raising urinary pH.
These results suggest that Glechoma longituba can be considered a better antiurolithic agent than potassium citrate.
Hence, Glechoma longituba offers promising potential as an antiurolithic agent.