Consequently, the restoration of miR-122 represents antitumorigenesis
functions that slow down the progression of both liver disease and HCC, which has been investigated and demonstrated in animal models .
Jeng et al., "Griseofulvin potentiates antitumorigenesis
effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells," International Journal of Cancer, vol.
In addition, MEL suppresses autophagy induced by ROS and sirtuins, both of which correlate with the circadian clock machinery and might contribute to antitumorigenesis
in the colon .
In this context, the involvement of pRB directs antitumorigenesis
via a conformational change in the local promoter region with or without epigenetic marks.