The second part is a multiple-group, noncomparative, indication expansion study to assess the preliminary antitumor
activity of the combination in patients with selected tumor types, in addition to further assessing the safety, tolerability and PK of the combination.
The stigmasterol , which is also named as stigmasta-5,22-dien-3beta-ol , exhibits strong activities in antitumor
, reducing the blood fat concentration, preventing and treating cardiovascular diseases.
Preclinical and clinical studies have demonstrated the intrinsic antitumor
capacity of Salmonella enterica (Table 1).
Du et al., "Epstein-Barr virus-induced gene 3 (EBI3) blocking leads to induce antitumor
cytotoxic t lymphocyte response and suppress tumor growth in colorectal cancer by bidirectional reciprocal-regulation STAT3 signaling pathway," Mediators of Inflammation, vol.
Increasing evidence has demonstrated that the adoptive transfer of tumor-specific [CD4.sup.+] T cells can exert a stronger antitumor
effect than [CD8.sup.+] T cells in cancer therapy [4, 12].
Antiangiogenic and antitumor
activities have enormously been enhanced by chemical oversulfation of fucoidan [64,65].
Since vast majority of intravenously injected MSCs initially become entrapped within the lungs where MSCs interact with tumor-infiltrated immune cells , we used metastatic model of murine lung cancer to investigate molecular and cellular mechanisms involved in MSC-mediated modulation of antitumor
immune response and progression of lung cancer metastasis.
While her research work is still inconclusive, it showed the potential of malunggay seeds as antitumor
In one animal tumor model, the antitumor
activity of the combination of Gp96 and HSP70 was superior to that of each protein alone.[sup] Here, we developed a vaccine comprising a mixture of HSP/Ps (mHSP/Ps), which included HSP60 and HSP110 in addition to HSP70 and Gp96, and evaluated its antitumor
effects in two mouse sarcoma models.
(1) The members of Interleukin (IL)-12 family consisting of heterodimeric cytokines including IL-12 and IL-27, are the most potent antitumor
All malignant tumors harbor genetic alterations, some of which may lead to the production of mutant proteins that are capable of triggering an antitumor
The findings support experimental evidence suggesting an antitumor
effect of statins on prostate carcinogenesis.