The patients included those with; pleural effusion of indeterminate origin, suspected tuberculous pleuritis not responding to the antituberculous
therapy after two months, fibrinopurulent or chronic empyema, suspected malignant effusion, interstitial lung disease not responding to the treatment, pulmonary nodule(s) suspected of malignant origin, myasthenia gravis and paratracheal/mediastinal mass.
The standard short-course chemotherapy for treatment of cutaneous tuberculosis which involves the administration of three antituberculous
drugs for the first two months (isoniazid 10 mg/Kg, rifampicin10 mg/Kg, pyrazinamide 30 mg/Kg), followed by four months of isoniazid and rifampicin was started.
In addition, following the initiation of specific antituberculous
treatment, the patient showed significant improvement in the knee and shoulder within two months with close to complete improvement within six months.
But some other studies which have shown that this is a reversible phenomenon which returns to normal with successful antituberculous
therapy, suspected tuberculosis of causing lymphocytopenia [3,11,13,14,17].
A combination of three antiretrovirals, four antituberculous
agents, co-trimoxazole (two drugs) and fluconazole is a common finding in ill AIDS patients who may also be hypoalbuminaemic and bed-ridden.
The patient was put on antituberculous
therapy for 6 months (rifampicin, isoniazid, pyrazinamide, and ethambutol for 2 months followed by rifampicin and isoniazid for 4 months) and concurrently treated for her skin conditions with topical sodium fusidate cream and 2% ketoconazole shampoo.
Excluding 5 patients whose first CSF sample was obtained more than 9 days after antituberculous
therapy was initiated, the sensitivity of the AMPLICOR test was 28.6% overall and 60.0% for those with definite or probable TB meningitis; specificity was 100% in all patient groups.
If the indicated repeat NAA testing fails to verify initial NAA test results, the clinician must rely on clinical judgement in decisions regarding the need for antituberculous
therapy, further diagnostic work-up, and isolation.
Such differentiation is utterly important in patient management; thus, in tuberculous spondylodiscitis, it requires minimal of 1-year antituberculous
Jarisch-Herxheimer reaction: paradoxical worsening of tuberculosis chorioretinitis following initiation of antituberculous
drugs were started after counseling the patient.
Granulomatouse mastitis is also diagnosed and required excision of mass with antituberculous