Dramatic increase of newly developed cases of TB worldwide that are caused by HIV co-infection and resistance to antituberculotic
drugs have led the World Health Organization (WHO) declare TB a global threat.
Horvati et al., "Membrane affinity of antituberculotic
drug conjugate using lipid monolayer containing mycolic acid," Colloids and surfaces.
The pharmacological achievements of the century in treatment of tuberculosis were streptomycin and other antituberculotic
Both strains were chosen due to their resistance to standard antimycobacterial therapy; therefore, isoniazid, pyrazinamide and rifampicin (as first-line antituberculotic
drugs), and ciprofloxacin (as an alternative antituberculotic/antimycobacterial drug) [42, 43] were used as standards.
In contrast, as noted above there is a good correlation between the [IC.sub.50] values for the inhibition of MtFabI and the antimycobacterial activity of 1-3, suggesting that these compounds may represent a profitable starting point for the development of novel antituberculotic