Studies in the Pacific have found a seroprevalence of antitreponemal
antibodies of >30% in several communities (7,17) and a prevalence of clinical yaws of ranging from 2.
Some experts argue that these represent false-positive screens because antitreponemal antibodies may persist long after treatment has eradicated the patient's infection.
Antitreponemal antibodies typically persist for life, so they are not suitable for monitoring disease.
76) Working at the Public Health Service's eponymous Venereal Disease Research Laboratory (VDRL) on Staten Island, John Mahoney discovered the antitreponemal
properties of penicillin in 1943.
In such cases, the CDC has recommended retesting samples with a second treponemal assay to confirm the presence of antitreponemal
A specific treponemal serologic test performed by overlaying whole treponemes that are fixed to a slide with serum from patients suspected of having syphilis and using fluorescein-conjugated antihuman antibody reagent to detect specific antitreponemal
antibodies is called which of the following?
Treponemal tests: Treponemal tests, including the FIA-Abs (fluorescent treponemal antibody absorption) test and syphilis immunoassays, detect antitreponemal
antibodies and indicate exposure to syphilis during the patient's lifetime.
Results for syphilis tests: Syphilis diagnostics in the republican blood centers are based on the Wassermann test, while the oblast blood center screens for Antitreponemal
Seropositive neonates without clinical evidence of syphilis are problematic because of possible passive transfer of maternal antitreponemal
An example of antitreponemal
antibody staining in a patient diagnosed with syphilis is shown in Figure 1.
He starts with Paul Ehrlich's antitreponemal
arsenicals and ends with the antisense agents now in early clinical trials for the treatment of autoimmune diseases and cancer, covering in the process the development of antibacterial and antiviral agents, vaccines, antimetabolites, and hormone-based antineoplastic agents.